高等学校化学学报 ›› 1993, Vol. 14 ›› Issue (2): 184.

• 研究论文 • 上一篇    下一篇

人尿中避孕药炔诺酮代谢物的GC-MS分析

张霁, 刘春胜, 周同惠   

  1. 中国协和医科大学, 中国医学科学院药物研究所, 北京 100050
  • 收稿日期:1992-04-16 修回日期:1992-10-10 出版日期:1993-02-24 发布日期:1993-02-24
  • 通讯作者: 刘春胜

The Analysis of Human Urine Metabolites of the Contraceptive Drug Norethisterone by GC-MS

ZHANG Ji, LIU Chun-Sheng, ZHOU Tong-Hui   

  1. Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing, 100050
  • Received:1992-04-16 Revised:1992-10-10 Online:1993-02-24 Published:1993-02-24

摘要: 本文用GC-MS方法分析炔诺酮及其在人尿中的代谢产物,从收集的服药后5h的尿样中检出并鉴定了炔诺酮的2个主要代谢物Met1和Met2,同时还发现2个浓度较低的次要代谢物Met3和Met4,与诺龙的代谢情况不同,容易区别。

关键词: 炔诺酮, 诺龙, 代谢物, GC-MS分析

Abstract: The analysis of human urine metabolites of norethisterone by GC-MSis presented.After a healthy female had orally taken 40 mg of norethisterone, her urine samples were collected and stored.Two main metabolites of norethisterone (Met 1, Met 2) were identified in the urine sample 5 h after taking norethisterone.According to previous research.there were two other metabolites of norethisterone (Met 3, Met 4)which were the same as those of nandrolone and thus would disturb the detection of the banned nandrolone in doping control test.However, our investigation shows that normally, the excretion concentration of Met 3 and Met 4 in human body are very low after the administration of norethisterone, which is easily distinguished from the case of administration of banned nandrolone in examination of athletes’ urine.

Key words: Norethisterone, Nandrolone, Metabolites, GC-MS analysis

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