高等学校化学学报 ›› 1993, Vol. 14 ›› Issue (10): 1363.

• 研究论文 • 上一篇    下一篇

磺苄青霉素药物电极的研究

孙立贤, 李有成, 俞汝勤   

  1. 湖南大学化学化工系, 长沙 410082
  • 收稿日期:1992-02-10 修回日期:1993-04-21 出版日期:1993-10-24 发布日期:1993-10-24
  • 通讯作者: 俞汝勤.
  • 作者简介:孙立贤, 男, 30岁, 博士研究生.
  • 基金资助:

    国家自然科学基金

The Study on a PVC Membrane Electrode for Sulbeaicillin

SUN Li-Xian, LI You-Cheng, YU Ru-Qin   

  1. Department of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082
  • Received:1992-02-10 Revised:1993-04-21 Online:1993-10-24 Published:1993-10-24

摘要: 报道了一种磺苄青霉素药物电极,以十六烷基三辛基碘化铵为载体,用邻苯二甲酸二壬酯为增塑剂;运用序贯淘汰水平法对膜组成进行了优化;确定了电极最佳膜组成,讨论了一些因素对电极性能的影响.电极响应快速,选择性、稳定性、重现性均较好.电极检测下限可达1.66×10-6mol/L,线性范围为6.03×10-6~1.0×10-1mol/L,斜率为28.0mV/pC,回收率为96.1%~100.4%.可用于磺苄青霉素药物的分析测定.

关键词: 磺苄青霉素, 药物电极, 序贯淘汰水平法, 化学计量学

Abstract: In this paper, a PVCmembrane electrode is prepared for sulbenicillin, 3,3-dimethyl-7-oxo-6-(2-phenyl-2-sulfoacetamido)-4-thia-1-azabicyclo [3, 2, 0] heptane-2-carboxylic acid, based on its ion pair complexes with hexadecyltrioctylammonium iodide (HTOA).Membrane composition of the electrode was optimized by using the sequential level elimination method for orthogonal experimental design.The electrode has a Nernst response range from 6.03×10-6-1.0× 10-1 mol/Lwith an average slope of 28.0 mV/pC.The limit of detection is 1.66×10-6.The electrode responses were not affected by pHin the range 6.3-7.0.The electrode was used for determining sulbenicillin in raw material of drug preparation with satisfactory results.

Key words: Sulbeniciliin, Drug electrode, Sequential level elimination method, Chemometrics

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