高等学校化学学报 ›› 1992, Vol. 13 ›› Issue (5): 697.

• 论文 • 上一篇    下一篇

含铜(Ⅱ)、铁(Ⅲ)、锰(Ⅱ)双核模型化合物的超氧化物歧化酶活性

廖展如1, 黄艳1, 石巨恩1, 刘长林2   

  1. 1. 华中师范大学化学系, 武汉, 430070;
    2. 华中理工大学化学系
  • 收稿日期:1991-04-06 出版日期:1992-05-24 发布日期:1992-05-24
  • 通讯作者: 廖展如
  • 基金资助:

    国家自然科学基金

The Superoxide Dismutase Activity of Binuclear Model Compounds Containing Copper (Ⅱ), Iron(Ⅲ) and Manganese (Ⅱ)

LIAO Zhan-ru1, HUANG Yan1, SHI Ju-en1, LU Chang-lin2   

  1. 1. Department of Chemistry, Huazhong Normal University, Wuhan, 430070;
    2. Department of Chemistry, Huazhong University of Science and Technology
  • Received:1991-04-06 Online:1992-05-24 Published:1992-05-24

摘要: 用邻苯三酚自氧化法测定自合成的N,N,N,N',N'-四(2'-苯并咪唑甲基)-1,4-二乙氨基乙二醚(EGTB)的双核铜(Ⅱ)、铁(Ⅲ)、锰(Ⅱ)配合物的超氧化物歧化酶活性,它们均在10-6~10-7mol/L的浓度范围内具有50%以上的抑制率。

关键词: 超氧化物歧化酶, 模型化合物, 活性检测

Abstract: We synthesized and characterized a ligand, N,N,N',N'-tetrakis (2'-benzimidazolyl methyl)-1,4-diethylene amino glycol ether (EGTB) and its binuclear complexes containing cop-per(Ⅱ), iron(Ⅲ) and manganese(Ⅱ).An assay of superoxide dismutase (SOD) activity was performed by means of pyrogallol autoxidation.It was found that all model compounds possess excellent SODactivity and they show more than 50% inhibition ratio in the concentration range of 10-6~10-7 mol/L of the complexes.

Key words: Superoxide dismutase, Model compound, Assay of activity

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