高等学校化学学报

高等学校化学学报 ›› 1992, Vol. 13 ›› Issue (5): 608.

• 论文 • 上一篇    下一篇

气相色谱-质谱联用法测定吸毒者尿中吗啡浓度

徐友宣1, 朱绍棠1, 张长久1, 吴筠1, 张友杰2   

  1. 1. 国家体委运动医学研究所兴奋剂检测中心, 北京, 100029;
    2. 华中师范大学测试中心
  • 收稿日期:1991-06-13 出版日期:1992-05-24 发布日期:1992-05-24
  • 通讯作者: 徐友宣

Determination of Morphine in Urine of Drug Addicts by Gas Chromatography-Mass Spectrometry

XU You-xuan1, ZHU Shao-tang1, ZHANG Chang-jiu1, WU Yun1, ZHANG You-jie2   

  1. 1. National Research Institute of Sports Medkine, Beijing, 100029;
    2. Analytical and Test Center of Center China Normal University, Wuhan
  • Received:1991-06-13 Online:1992-05-24 Published:1992-05-24

PDF (PC)

被引次数

2

摘要： 本文建立了测定吸毒者尿中吗啡浓度的方法,样品经酸解、醚洗、碱化及溶剂提取后,用MSTFA衍生化,最后用GC/MS(SIM)法分析,以内标法定量。

关键词: 吗啡, 吸毒者, 气相色谱-质论联用

Abstract: A rapid sensitive method has been developed for the determination of the concentration of morphine in drug addicts'urine by using GC/MScombined with Selected Ion Monitoring (SIM) technique.The peak area ratio of morphine to dihydrocodeine(internal standard) is proportional to the concentration of morphine from 10 ng/mLto 1000 ng/mL.The recovery and detection limit are 96.6±1.8(n=4) and 0.5 ng.The method has been used to determine the concentration of drug addicts who were being treated in a hospital.

Key words: Morphine, Drug addicts, Gas chromatography-mass spectrometry

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