5-烃基-2,3-二甲基吡嗪N-单氧化物的合成

高等学校化学学报 ›› 1992, Vol. 13 ›› Issue (1): 70.

5-烃基-2,3-二甲基吡嗪N-单氧化物的合成

蔡松传, 赵焘南, 孙德华, 张道信, 包燕雏

南京大学化学系, 南京, 210008

收稿日期:1991-01-03 出版日期:1992-01-24 发布日期:1992-01-24
通讯作者: 蔡松传

Synthesis of 5-Alkyl-2,3-Dimethylpyrazine-mono-N-Oxides

CAI Song-chuan, ZHAO Tao-nan, SUN De-hua, ZHANG Dao-xin, BAO Yan-chu

Department of Chemistry, Nanjing University, Nanjing, 210008

Received:1991-01-03 Online:1992-01-24 Published:1992-01-24

摘要/Abstract

关键词: 5-烃基-2, 3-二甲基吡嗪, N-氧化反应, 5-烃基-2, 3-二甲基吡嗪-1-N-氧化物

Abstract: N-oxidation of 5-alkyl-2, 3-dimethylpyrazines with 30% H₂O₂-AcOHusually gives 1-N-oxides, 4-N-oxides and 1,4-N-dioxides.When the molar ratio of pyrazines/H₂O₂/AcOHis 1 : 1.2 : 15 at 70℃, the reaction is gives mono-N-oxides with best yields.N-oxidation of ten 5-alkyl-2,3-dimethylpyrazines were carried out under the above conditions, giving thirteen new compounds 5-alkyl-2,3-dimethylpyrazine-mono-N--oxid.es with satisfactory yields (50%～70%).Their structures were confirmed by elemental analysis, IR,¹H NMRand MSspectrometry.The structures of 1-N-oxides and 4-N-oxides were determined on the basis of ¹H NMRspectral data, since the N-oxide group in substituted pyrazine mono-N-oxides gives the anisotropic effect.Additionally, the structures of eight new 1,4-N-dioxides obtained were confirmed by elemental analysis, IRand ¹H NMRspectrometry.

Key words: 5-Alkyl-2,3-dimethyipyrazine, N-Oxidation, 5-Alkyl-2,3-dimethylpyrazine 1-N-oxide

TrendMD:

蔡松传, 赵焘南, 孙德华, 张道信, 包燕雏. 5-烃基-2,3-二甲基吡嗪N-单氧化物的合成. 高等学校化学学报, 1992, 13(1): 70.

CAI Song-chuan, ZHAO Tao-nan, SUN De-hua, ZHANG Dao-xin, BAO Yan-chu . Synthesis of 5-Alkyl-2,3-Dimethylpyrazine-mono-N-Oxides. Chem. J. Chinese Universities, 1992, 13(1): 70.