新农药研究(Ⅲ)--咪唑啉酮类化合物的合成

高等学校化学学报 ›› 1991, Vol. 12 ›› Issue (7): 912.

新农药研究(Ⅲ)--咪唑啉酮类化合物的合成

王立坤, 李正名, 刘同柱, 蒋益民

南开大学元索有机化学研究所, 天津, 300071

收稿日期:1990-03-15 出版日期:1991-07-24 发布日期:1991-07-24
通讯作者: 李正名

The Research on Development of Novel Pesticides (Ⅲ)--The Synthesis of Imidazolinones

Wang Li-kun, Li Zheng-ming, Liu Tong-zhu, Jiang Yi-min

Institute of Elemento-Organic Chemistry, Nankai University., Tianjin, 300071

Received:1990-03-15 Online:1991-07-24 Published:1991-07-24

摘要/Abstract

摘要： Rovral[3-(3,5-二氯苯基)-1-异丙氨基甲酰乙内酰脲]是一种优良的广谱杀菌剂和种子处理剂,由于3,5-二氯苯胺不易制备,本文采用其它取代苯胺作为起始原料,采用固态光气制备异氰酸酯,中间体未经分离,经缩合、关环"一锅法"反应,得到化合物Ⅰ,进一步反应得到Ⅱ、Ⅲ系列新化合物。

关键词: 咪唑啉酮, 环化合成, 三聚光气

Abstract: 3-(3,5-dichlorophenyl)-1-isopropyl-carbamoylhydantoin has been developed as a commercial fungicide known as R'oyral. Nevertheless, the starting material 3,5-dichloroaniline for the synthesis is not easily available. The latter was replaced by other substituted anilines here, followed by conversion to isocyanates by triphosgene and cyclization into heterocycles in one-pot reaction. 22 new compounds were synthesized with all structures confirmed by elementary analysis,IR, NMR and MS. Biological screening indicated that 5 compounds were effective against black rot of apple (Physalospora piricola Nose).

Key words: Imldazolinone, Cyclization, Triphosgene

TrendMD:

王立坤, 李正名, 刘同柱, 蒋益民. 新农药研究(Ⅲ)--咪唑啉酮类化合物的合成. 高等学校化学学报, 1991, 12(7): 912.

Wang Li-kun, Li Zheng-ming, Liu Tong-zhu, Jiang Yi-min . The Research on Development of Novel Pesticides (Ⅲ)--The Synthesis of Imidazolinones. Chem. J. Chinese Universities, 1991, 12(7): 912.