高等学校化学学报

高等学校化学学报 ›› 1991, Vol. 12 ›› Issue (6): 771.

• 论文 • 上一篇    下一篇

血癌调节剂--(4S,5R)-5-羟基-4-癸内酯的合成

陆忠娥, 孙大庆, 陈克潜, 徐海剑   

  1. 苏州大学化学系, 苏州, 2l5006
  • 收稿日期:1990-06-22 出版日期:1991-06-24 发布日期:1991-06-24
  • 通讯作者: 孙大庆

Synthesis of (4S, 5R)-5-Hydroxy-4-Decanolide, the Autoregulator of Blood Cancer from Streptomyces Griseus

Lu Zhong-e, Sun Da-qins, Chen Ke-qian, Xu Hai-jian   

  1. Department of Chemistry, Suzhou University, Suzhou, 215006
  • Received:1990-06-22 Online:1991-06-24 Published:1991-06-24

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摘要： (4S,5R)-5-羟基-4-癸内酯1对血癌具有调节作用。本文首先利用Sharpless动力学拆分反应制得光学活性的环氧化合物,然后再通过其它反应合成具有生理活性的化合物1。

关键词: 血癌调节剂, Sharpless动力学拆分, 癸内酯

Abstract: (4S, 5R)-5-hydroxy-4-decanolide 1, the proposed autoregulator of blood cancer from Streptomyces griseus was synthesized from an allyl alcohol 2, employing the Sharpless kinetic resolution and the reaction of diethyl malonate with epoxy compound 4 as two key steps.

Key words: Autoregulator of blood cancer, Sharpless kinetic resolution, Decanolide

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