异色满酮-4及其衍生物的合成(Ⅳ)--辛可宁酸类似物的合成

高等学校化学学报 ›› 1991, Vol. 12 ›› Issue (1): 59.

异色满酮-4及其衍生物的合成(Ⅳ)--辛可宁酸类似物的合成

王进军, 尹炳柱, 姜贵吉

延边大学化学系, 133002

收稿日期:1989-06-27 出版日期:1991-01-24 发布日期:1991-01-24
通讯作者: 姜贵吉

Synthesis of Isochroman-4-one and Its Derivatives (Ⅳ)--Preparation of Analogues of Cinchophen

Wang Jin-jun, Yin Bing-zhu, Jiang Gui-ji

Department of Chemistry, Yanbian University, Yanji, 133002

Received:1989-06-27 Online:1991-01-24 Published:1991-01-24

摘要/Abstract

摘要： 由异色满酮-4(1)与邻氨基苯甲醛或邻氨基胡椒醛进行Friedlender缩合反应得到异色满并喹啉衍生物异色满并[4,3-b]喹啉(2)和9,10-亚甲二氧基异色满并[4,3-b]喹啉(3).

关键词: 异色满酮-4, 7-羧基异色满并[4, 3-b]喹啉, 抗炎作用

Abstract: Isochromano-[4,3-b] quinoline(2) and 9,10-methylenedioxyisochromano-[4,3-b] quino-line (3) are obtained, respectively, by condensing isochromanone (1) with o-aminobenzaldehyde and o-amino piperonal in the presence of sodium ethoxide. The new derivatives of 7-carboxyisochromano [4,3-b] quinoline (4a～e) are obtained by the reaction of (1) with isatins in a satisfactory yield. Es-terification of (4c) can be transformed into (5) which has a new cinchophen-like structure. Compound (4a) and (5) show a good antiphlogistic activity.

Key words: Isochroma-4-one, 7-Carboxyisochromano-[4,3-b] quinoline, Antiphlogistic activity

TrendMD:

王进军, 尹炳柱, 姜贵吉. 异色满酮-4及其衍生物的合成(Ⅳ)--辛可宁酸类似物的合成. 高等学校化学学报, 1991, 12(1): 59.

Wang Jin-jun, Yin Bing-zhu, Jiang Gui-ji . Synthesis of Isochroman-4-one and Its Derivatives (Ⅳ)--Preparation of Analogues of Cinchophen. Chem. J. Chinese Universities, 1991, 12(1): 59.