血卟啉衍生物钠盐溶液避光放置时新卟啉物的形成

高等学校化学学报 ›› 1989, Vol. 10 ›› Issue (6): 644.

血卟啉衍生物钠盐溶液避光放置时新卟啉物的形成

邱宇华, 张维德, 严学明

中国科学技术大学结构成分分析中心

收稿日期:1987-09-30 出版日期:1989-06-24 发布日期:1989-06-24
通讯作者: 严学明

The Formation of New Porphyrin Species(NPS) from Hematoporphyrin Derivatives (HPD) in Sodium Saline Solution by Standing away from the Light

Qiu Yuluia, Zhang Weide, Yan Xueming

Central Leboratory of Structure and Element Analysis, University of Science and Technology of China, Hefei

Received:1987-09-30 Online:1989-06-24 Published:1989-06-24

摘要/Abstract

摘要： 血卟啉衍生物HPD溶液在盐溶液中稀释并避光放置时,其光谱特性发生明显变化,形成荧光发射峰在580nm的新荧光物质(NPS)。有关NPS的研究已有一些报道^[1～4],因此搞清NPS的组成和结构,研究NPS的形成对HPD光敏化作用的影响是很有意义的。

关键词: 血卟啉衍生物HPD, 新卟啉物NPS, 坐顶络合物

Abstract: After HPDin sodium saline solution standing away from the light, NPSis formed. It shows an absorption/excitation peak at 403 nm, an emission peak at 580 nm. Its formation is strongly influenced by many factors, in particular, irradiation, temperature, pH, concentration and gases diluted in thesolution. NPSwas tentatively identified as a complexing intermediate ------"thesitting-at top complex" formed by combining HPDwith sodium ion in the solvent. The formation of NPSprobably brings about unfavourable influence upon the photosensitive capacity of HPDin cancer tissues.

Key words: Hematoporphyrin derivatives (HPD), New porphyrin species (NFS), The Sitting-at top complex

TrendMD:

邱宇华, 张维德, 严学明. 血卟啉衍生物钠盐溶液避光放置时新卟啉物的形成. 高等学校化学学报, 1989, 10(6): 644.

Qiu Yuluia, Zhang Weide, Yan Xueming. The Formation of New Porphyrin Species(NPS) from Hematoporphyrin Derivatives (HPD) in Sodium Saline Solution by Standing away from the Light. Chem. J. Chinese Universities, 1989, 10(6): 644.