高等学校化学学报

高等学校化学学报 ›› 1989, Vol. 10 ›› Issue (3): 311.

• 研究简报 • 上一篇    下一篇

一种新的电解方式对苯乙酮不对称电还原的影响

李宁, 陈琪瑞, 庞开圻   

  1. 沈阳药学院
  • 收稿日期:1987-10-09 出版日期:1989-03-24 发布日期:1989-03-24
  • 通讯作者: 陈琪瑞
  • 基金资助:

    国家自然科学研究基金

The Effect of a New Electrolysis Mode on Asymmetric Reduction of Acetophenone

Li Ning, Chen Qirui, Pang Kaiqi   

  1. Shenyang College of Pharmacy
  • Received:1987-10-09 Online:1989-03-24 Published:1989-03-24

PDF (PC)

被引次数

1

摘要： 近十几年来,不对称电合成越来越受到重视。有关苯乙酮不对称电还原已有过不少报道。其中Kariv用奎尼丁作手性吸附诱导剂时,光学收率最高为14.5%。1984年,我们实验室曾以盐酸士的宁为手性吸附诱导剂对苯乙酮进行不对称电还原,光学收率为9.7%,又以四环素类抗菌素为手性吸附诱导剂,得到α-苯乙醇的光学收率为4.8～18.5%。本文研究了不同电解方式和通电量对α-苯乙醇光学收率与化学收率的影响。实验证明静态薄液层电解法优于Kariv的滴加搅拌法,前者可使α-苯乙醇的光学收率达21.8%。

关键词: 苯乙酮, 士的宁, 不对称电还原

Abstract: This paper reports that acetophenone was reduced by asymmetric electrolysis with strychnine as a chiral inductor. The effect of the mode of electrolysis and the quantity of electricity on the reaction was investigated. It was found that the static-thin-layer mode was better than Kariv's method, the optical yield of a-carbinol was increased from 14.7% to 21.8%.

Key words: Acetophenone, Strychnine, Asymmetric electroysis

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