苯丙胺类化合物合成的研究

高等学校化学学报 ›› 1988, Vol. 9 ›› Issue (2): 134.

苯丙胺类化合物合成的研究

苏镜娱, 郑义森, 吴建青, 汤干明, 曾陇梅

中山大学化学系

收稿日期:1986-09-09 出版日期:1988-02-24 发布日期:1988-02-24

The Synthesis of 2-Amino-1-Phenylpropanes

Su Jingyu, Zheng Yishen, Wu Jianqing, Tang Ganming, Zeng Longmei

Department of Chemistry, Zhongahan University, Guangzhou

Received:1986-09-09 Online:1988-02-24 Published:1988-02-24

摘要/Abstract

摘要： 通过1-苯基-2-丙酮路线合成了笨丙胺类化合物。经核磁共振谱分析,发现文献报道的产物,实际上是氟笨丙胺的异构体。本文对该法的每一步反应的重排产物进行了研究,并对该法中氨基化的一步作了改进。

Abstract: 2-Amino-1-phenylpropanes are useful ideal appetite depressants. Among them, 2-N-ethylamino-1-(m-trifluorornethyl)pheny]propanc (Fenfluramine) is most important.Aconvenient method for the syntheses of these compounds is described in this paper. With benzyl methyl ketone as intermediate, the target compounds were successfully obtained from reductive amination reaction in quite reasonable yields. According to the ¹HNMR,it was found that the product yielded by the approach of Y.A.Larionova[4] was :not 2-N-ethylamino-1-(m-trifluoromethyl)phcnylpropane but its rearranged isomer. The stepwise rearrangement products was carefully examined by ¹HNMRand some improvement in amination was reported.

TrendMD:

苏镜娱, 郑义森, 吴建青, 汤干明, 曾陇梅. 苯丙胺类化合物合成的研究. 高等学校化学学报, 1988, 9(2): 134.

Su Jingyu, Zheng Yishen, Wu Jianqing, Tang Ganming, Zeng Longmei . The Synthesis of 2-Amino-1-Phenylpropanes. Chem. J. Chinese Universities, 1988, 9(2): 134.