载有5-FU的聚乙烯醇高聚物的合成

高等学校化学学报 ›› 1987, Vol. 8 ›› Issue (8): 758.

载有5-FU的聚乙烯醇高聚物的合成

周朝华, 张炜

兰州大学化学系

收稿日期:1986-01-27 出版日期:1987-08-24 发布日期:1987-08-24

The Synthesis of Polymers of Polyvinyl Alcohol Linking 5-FU

Zhou Chaohua, Zhang Wei

Department of Chemistry, Lanzhou University, Lanzhou

Received:1986-01-27 Online:1987-08-24 Published:1987-08-24

摘要/Abstract

摘要： 5-FU具有抗瘤谱广、有效率高的特点,但在体内代谢快、有效期短,而且毒副作用较严重,近年来,人们发现将5-FU通过化学键与天然的或合成的高分子相连,可以得到具有潜在活性的高分子抗肿瘤药。

Abstract: By the reactions of three kinds of sodium poly vinyl alcohol of different average molecular weight with 1-(chloroacetyl)-5-fluorouracil(AF) or l-(2-chloro-propionyl)-5-fluorouracil (PF) in absolute DMSO, six kinds of new polymers were prepared. Meanwhile, the influence of reaction conditions and average molecular weight of polyvinyl alcohol on the new polymers was studied systematically. The structural characteristics of the new polymers were investigated by IR and UV; hydrolysis of the new polymers in various buffer solutions (pH1.5, 7.0 and 9.0) was measured by UV, and it was obvious that the new polymers could release out 5-FU.

TrendMD:

周朝华, 张炜. 载有5-FU的聚乙烯醇高聚物的合成. 高等学校化学学报, 1987, 8(8): 758.

Zhou Chaohua, Zhang Wei . The Synthesis of Polymers of Polyvinyl Alcohol Linking 5-FU. Chem. J. Chinese Universities, 1987, 8(8): 758.