高等学校化学学报 ›› 1987, Vol. 8 ›› Issue (1): 36.
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凌仰之, 徐艳娜, 李安良, 刘维勤
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中国科学院科学基金
Ling Yangzhi, Xu Yanna, Li Anliang, Liu Weiqin
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摘要: 从三氟甲苯始,经溴化、格氏反应、缩合、溴(或氯)加成等反应,合成了九个α-卤代-间-三氟甲基桂皮酰胺和二个α,β-二卤代-间-三氟甲基苯丙酰另丁胺等衍生物。用核磁共振氢谱确定了其Z、E构型。药理结果表明,α-卤素的引入,其抗惊活性未见增强。
Abstract: Nine α-halo-m-trifluoromethyl cinnamides were synthesi2ed from trjfluoro-methyl benzene, via bromination, Grignard reaction, condensation, halogen addition reactions etc, as indicated in the synthetic scheme. Their configurations were confirmed by NMR. Their pharmacological results showed that, the introduction of α-halogen group, did not enhance their anticonvulsant activity as expected.
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凌仰之, 徐艳娜, 李安良, 刘维勤. α-卤代-间-三氟甲基桂皮酰胺类化合物的合成及其抗惊活性的探讨. 高等学校化学学报, 1987, 8(1): 36.
Ling Yangzhi, Xu Yanna, Li Anliang, Liu Weiqin . The Synthesis and Anticonvulsant Activity of Some α-Halo-m-Trifluoromethyl Cinnamamides. Chem. J. Chinese Universities, 1987, 8(1): 36.
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