O-芳基苯基硫代膦酰肼及其旋光活性腙

高等学校化学学报 ›› 1986, Vol. 7 ›› Issue (9): 811.

O-芳基苯基硫代膦酰肼及其旋光活性腙

陈茹玉, 金桂玉, 沙跃武

南开大学元素有机化学研究所

收稿日期:1985-06-04 出版日期:1986-09-24 发布日期:1986-09-24
基金资助:
中国科学院基金资助课题

Aryloxyphenylthiophosphonyl Hydrazide and Its Optically Active Hydrazone

Chen Ruyu, Jin Guiyu, Sha Yuewu

Institute of ElemertoOrganie Chemistry, Nankai University, Tianjin

Received:1985-06-04 Online:1986-09-24 Published:1986-09-24

摘要/Abstract

摘要： 某些膦酰肼及其衍生物只有生物活性。本文通过O-芳基苯基硫代膦酰氯与50％水合肼反应合成了O-芳基苯基硫代膦酰肼(Ⅰ),在有些反应中还分离到N,N′-双[O-芳基苯基硫代膦酰基]肼(Ⅱ)。Ⅰ与(-)-薄荷酮反应得旋光活性薄荷酮腙(Ⅲ),由于磷原子是手性的,产物为非对映异构体。

Abstract: Aryloxyphcnylthiophosphonyl hydrazidc (Ⅰ) has been synthesized by the reaction of aryloxyphcnylthiophospllcny! hloridc with excess of 50% hydrazinehydratc and NN'-bis [aryloxyphenylthiophosphoyl] hydrazidc (Ⅱ) was isolated in some of these reaction.The Diastereomer of optically active hydrazone were obtained by the reaction of (Ⅰ)with (-) mcnthonc.One of the optical isomcr of ethoxyphenyl-thiophosphonyl(-)menthonc hydrazone was chromatographed with the silica gel co-lumn,IR,¹H NMRand Mass Spectra of the title compounds were discussed.

TrendMD:

陈茹玉, 金桂玉, 沙跃武. O-芳基苯基硫代膦酰肼及其旋光活性腙. 高等学校化学学报, 1986, 7(9): 811.

Chen Ruyu, Jin Guiyu, Sha Yuewu . Aryloxyphenylthiophosphonyl Hydrazide and Its Optically Active Hydrazone. Chem. J. Chinese Universities, 1986, 7(9): 811.