螯合剂与牛血清白蛋白竞争镉作用的研究

高等学校化学学报 ›› 1986, Vol. 7 ›› Issue (7): 571.

螯合剂与牛血清白蛋白竞争镉作用的研究

李荣昌¹, 陈宝卫¹, 王夔¹, 吴永慧², 王祥云²

1. 北京医科大学药物药理实验室;
2. 北京大学技术物理系

收稿日期:1985-04-16 出版日期:1986-07-24 发布日期:1986-07-24
基金资助:
中国科学院科学基金

Studies of the Competition for Cadmium Ion Between Chelating Agents and Bovine Serum Albumin

Li Rongchang¹, Chen Baowei¹, Wang Kui¹, Wang Xiangyun², Wu Yonghui²

1. Institute of Pharmaceutical Science Beijing Melical Univrsity, Beijing;
2. Department of Technical Physics Peking University, Beijing

Received:1985-04-16 Online:1986-07-24 Published:1986-07-24

摘要/Abstract

摘要： 研究了十一种螯合剂使结合在牛血清白蛋白(BSA)上的镉活动化的能力。由凝胶色谱法测得的F值将螯合剂活动镉的能力排成以下顺序:DTP>EDTA>EGTA>NTA>TRIEN>;PEN>CYS>HIS>SA氨羧络合剂型配体能有效地与BSA竞争,而且它们的lgF与lgK_CdL间有一线性关系。

Abstract: Eleven chelating agents were studied for their ability to mobilize the cadmium bound to bovine serum albumin (BSA).Thc parameter F,which is defined as the ratio between the percentages of Cd bound to BSAin the presence and absence of chelating agents,can be used as the criterion for the estimation of the mobilizing ability of chelating agents.The Fvalues determined experimentally lead to a mobilizing ability sequence DTPA>EDTA>EGTA>NTA>TRIEN>PEN>CYS>HIS>SAThe polyaminopolycarboxylate type chelators mobilize Cd effectively.Alinear relationship is found between lgFand lgK_CJL (conditional stability constant of the cadmium chelates) for all the chelators except the mcrcapto-compounds.The anomalous behavior of the mercaplo-chelate agents is discussed.

TrendMD:

李荣昌, 陈宝卫, 王夔, 吴永慧, 王祥云. 螯合剂与牛血清白蛋白竞争镉作用的研究. 高等学校化学学报, 1986, 7(7): 571.

Li Rongchang, Chen Baowei, Wang Kui, Wang Xiangyun, Wu Yonghui. Studies of the Competition for Cadmium Ion Between Chelating Agents and Bovine Serum Albumin. Chem. J. Chinese Universities, 1986, 7(7): 571.