高等学校化学学报

高等学校化学学报 ›› 1985, Vol. 6 ›› Issue (10): 903.

• 研究论文 • 上一篇    下一篇

环状核苷酸衍生物的合成

张礼和, 马灵台, 徐成, 董令娇, 王奇, 王序   

  1. 北京医学院药学系
  • 收稿日期:1984-08-02 出版日期:1985-10-23 发布日期:1985-10-23

The Syntheses of Derivatives of Nucleoside 3',5' -Cyclic Phosphate

Zhang Lihe, Ma Lintai, Xu Chen, Dong Lingjiao, Wang Qi, Wang Xu   

  1. Department of Pharmaceutical Sciences, Beijing Medical College, Beijing
  • Received:1984-08-02 Online:1985-10-23 Published:1985-10-23

PDF (PC)

被引次数

9

摘要： 2'-O-对甲苯磺酰基-c-AMP以对甲苯磺酰氯或三苯基膦/四氯化碳作缩合剂,与不同醇或胺反座得到3',5'-环核苷酸磷酸酯或磷酰胺,以上他合物在乙二醇二甲醚中于-60°用茶化钠或蒽化钠反应可以脱去对甲苯磺酰基,同时分离了这些磷酸酯或磷酰胺的立体异构体。

Abstract: By using tosyl chloride or triphenyl phosphine/carbon tetrachloride as condensing reagents, 2'-tosyl c-AMPreacted with ROHor RNH2 to give nucleoside 3',5'-cyclic phosphotri-esters and phosphoramidates in 30-60% yield. Detosylation was carried out by using sodium naphthaline at -60℃+ in DMEin 70-90% yield. The stereoisomers of these compounds have been separated and the structures have been identified by 1H NMR, 13C NMR, 31P NMRand FDMS.

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