高等学校化学学报 ›› 1984, Vol. 5 ›› Issue (4): 503.

• 论文 • 上一篇    下一篇

毛冬青甙甲的结构研究(Ⅰ)

曾陇梅1, 苏镜娱1, 张树德2   

  1. 1. 中山大学化学系;
    2. 中国科学院生物物理研究所
  • 收稿日期:1982-12-13 出版日期:1984-10-24 发布日期:1984-10-24

Studies on the Chemical Structure of Ilexolide A (Ⅰ)

Zeng Lonmei1, Su Jingyu1, Zhang Shude2   

  1. 1. Department of Chemistry, Zhongshan Uniersity, Guangzhou;
    2. Institute of Boiphysics, Academia Sinica, Beijing
  • Received:1982-12-13 Online:1984-10-24 Published:1984-10-24

摘要: 从毛冬青根分离出一种具有强心作用的新的三萜甙——毛冬青甙甲(I)。分析证明(Ⅰ)为毛冬青酸(Ⅱ)的β-木糖甙。(Ⅱ)是新的三萜酸,经化学反应和波谱分析推定其结构为18-去氢-20-表乌苏酸。X射线单晶衍射分析确证了毛冬青酸的结构及其立体化学。

Abstract: Ilex publesccns Hook et Am is an evergreen bush. It is used in China as a herb medicine. We have isolated from the root a new triterpenc glyco-side, namely ilexolide A, which exhibits cardiac activity.Ilexolide A ( I ) is a white amorphous solid, m. p. 214-216℃, [α]D + 54.5(c, 0.83, alc.). It was hydrolyzed to afford the aglycone, ilexolic acid (Ⅱ), m. p. 288-289℃, [α]D + 437 (c. 0.89 DMF). Ilexolide Ais xyloside of ilexolic acid (Ⅱ).Ilexolic acid, C30H46O3 (M+ 454.3463) is a new triterpene acid having the structure of (Ⅱ). Its structure has been determinated by a series of characteristic chemical reactions and spectroscopic methods. MS, NMR and IR. In order to establish the structure and stereochemistry, single crystal X-ray structure analysis has been taken.

TrendMD: