高等学校化学学报

高等学校化学学报 ›› 1984, Vol. 5 ›› Issue (1): 1.

• 论文 •    下一篇

反式二氯二氨合铂与核苷作用的13C核磁共振研究

唐雯霞, 张士勇, 袁传荣, 戴安邦   

  1. 南京大学配位化学研究所
  • 收稿日期:1982-08-18 出版日期:1984-02-24 发布日期:1984-02-24

STUDY ON THE INTERACTION OF TRANS-[Pt(NH3)2Cl2] WITH NUCLEOSIDES BY 13C NMR

Tang Wenxia, Zhang Shiyong, Yuan Chuanrong, Tai An-pang   

  1. Coordination Chemistry Institute, Nanjing University, Nanjing
  • Received:1982-08-18 Online:1984-02-24 Published:1984-02-24

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摘要： 本文用13C核磁共振法研究了反式二氯二氨合铂和胸苷、胞苷、鸟苷和5'-腺苷酸的作用,确定在中性介质中所生成配合物状态及其中铂与配体的健合形式,在此基础上讨论了顺、反式二氯二氨合铂具有不同抗癌行为的可能原因。

Abstract: Interaction of trans-[Pt(NH3)3Cl213C NMR. The formation of a series of complexes and the site of complexation of nucleosides (or nucleotide) to trans-[Pt(NH3)2Cl2] in the reaction systems were ascertained. On the basis of the results obtained, a possible reasoning of different behaviours of cis-, trans-[Pt(NH3)2 Cl2] in antitumour action was discussed.

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