高等学校化学学报

高等学校化学学报 ›› 1983, Vol. 4 ›› Issue (4): 523.

• 论文 • 上一篇    下一篇

保存突变蛋白质间氨基酸取代规律性的研究(Ⅰ)——不同种属来源胰岛素的构象分析

程玉华, 张学忠, 佟祥山   

  1. 吉林大学化学系
  • 收稿日期:1981-09-05 出版日期:1983-08-24 发布日期:1983-08-24

STUDIES ON REGULARITY OF AMINO ACIDS REPLACEMENT IN HOMOLOGOUS PROTEINS (Ⅰ)——CQNFQRMATIONAL ANALYSIS OF INSULINS FROM DIFFERENT SPECIES

Cheng Yuhua, Zhang Xuezhong, Tong Xiangshan   

  1. Department of Chemistry, Jilin University, Changchun
  • Received:1981-09-05 Online:1983-08-24 Published:1983-08-24

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摘要： 本文研究了同源胰岛素间氨基酸取代的规律性。发现,保存突变不是随机进行的:在刚性结构上,取代氨基酸之间具有十分一致的构象参数;在螺旋的不同侧面上,氨基酸取代的频率是有很大差异的。

Abstract: In this article the regularity of amino acid replacement among ho-mologues insulins was explored. It is shown that the reservational mutants are developed along no-random way: in the rigit structures of protein, replaced amino acids possess similar conformational parameters; a(?)varied side of α-helix frequency of replacement of amino acids is different from each other.

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