高等学校化学学报 ›› 1983, Vol. 4 ›› Issue (2): 201.

• 论文 • 上一篇    下一篇

去甲斑蝥酰亚胺及其类似物的N-Mannich碱

陈光旭, 赵信岐   

  1. 北京师范大学化学系
  • 收稿日期:1981-11-30 出版日期:1983-04-24 发布日期:1983-04-24

N-MANNICH BASES OF NORCANTHARIDINIMIDE AND ANALOGS

Chen Guangxu, Zhao Xinqi   

  1. Department of Chemistry, Peking Normal University, Beijing
  • Received:1981-11-30 Online:1983-04-24 Published:1983-04-24

摘要: 本文报导7-氧杂双环[2,2,1]庚-5-烯-2,3-二酰亚胺及其还原产物——去甲斑螯酰亚胺的制备及其某些化学反应。由这两种酰亚胺出发,合成了35种新的N-Mannich碱。鉴于文献报导类似结构化合物的生理活性,我们合成的N-Mannich碱有可能也具有某种生理活性。

Abstract: Norcantharidinimide, 7-oxabicyclo [2, 2, 1] heptane-2,3-dicarboximide and its deaydroderivative, 7-oxabicyclo [2,2,l]-hept-5-ene-2, 3-dicarboxi-mide, were found to readily undergo Mannich reaction with primary or secondary amine to form N-Mannich bases in good yields. Thirty-five N-Mannich bases of this type were prepared from both aliphatic and aromatic amines.

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