高等学校化学学报 ›› 1981, Vol. 2 ›› Issue (1): 50.

• 论文 • 上一篇    下一篇

1-异烟酰基-4-芳酰基氨基硫脲化合物的研究

张自义, 陈立民   

  1. 兰州大学化学系
  • 收稿日期:1979-12-25 出版日期:1981-01-24 发布日期:1981-01-24

A STUDY OF 1-ISONICOTINOYL-4-AROYLTHIOSEMICARBAZIDES COMPOUNDS

Zhang Ziyi, Chen Limin   

  1. Department of Chemistry, Lanzhou University, Lanzhou
  • Received:1979-12-25 Online:1981-01-24 Published:1981-01-24

摘要: 进一步研究了卤代芳酰异硫氰与异烟酰肼反应,制得一系列1-异烟酰基-4-卤代芳酰基氨基硫脲,并观察了这些新药物的抗结核菌性能,其中以1-异烟酰基-4-对碘苯甲酰基-氨基硫脲抗结核菌作用最强。

Abstract: For the purpose of studying the relation between molecular structure and tuberculostatic activity in acylthiosemicarbazide group, some new derivatives of thiosemicarbazide such as 1-isonicotinoyl-4-halogen-aroyl-thiosemicarbazides have been synthesized.These new compounds ware prepared by developing the reaction of the halogen aroylisothiocyanate with isonicotinoyl hydrazide In acetone, acetonitrile or djoxane in yield of 50-80%.

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