高等学校化学学报

高等学校化学学报 ›› 2012, Vol. 33 ›› Issue (11): 2390.doi: 10.7503/cjcu20120410

• 分析化学 • 上一篇    下一篇

傅里叶变换红外光谱体表无创探测乳腺肿瘤

申伟1, 赵红梅1, 雷玉涛1, 凌晓锋1, 祝青2, 张应2, 张元福2, 徐怡庄2, 吴瑾光2, 武阳丰3, 李会娟3, 徐智1   

  1. 1. 北京大学第三医院普通外科, 北京 100191;
    2. 北京大学化学与分子工程学院, 北京 100871;
    3. 北京大学临床研究所, 北京 100191
  • 收稿日期:2012-04-27 出版日期:2012-11-10 发布日期:2012-10-15
  • 通讯作者: 徐智,男,教授,主要从事外科疾病的临床和分子光谱研究.E-mail:xuzhi123456@sohu.com E-mail:xuzhi123456@sohu.com
  • 基金资助:

    中央高校基本科研业务费专项-北京大学临床研究项目(批准号: PUCRP201105)和北京市自然科学基金(批准号:2122059)资助.

Surface Noninvasive Detection of Breast Tumors Using Fourier Transform Infrared Spectroscopy

SHEN Wei1, ZHAO Hong-Mei1, LEI Yu-Tao1, LING Xiao-Feng1, ZHU Qing2, ZHANG Ying2, ZHANG Yuan-Fu2, XU Yi-Zhuang2, WU Jin-Guang2, WU Yang-Feng3, LI Hui-Juan3, XU Zhi1   

  1. 1. Department of General Surgery, Peking University Third Hospital, Beijing 100191, China;
    2. College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China;
    3. Peking University Clinical Research Institute, Beijing 100191, China
  • Received:2012-04-27 Online:2012-11-10 Published:2012-10-15

PDF (PC)

被引次数

13

摘要：

利用傅里叶变换红外(FTIR)光谱仪联合衰减全反射(ATR)探头的中红外光导纤维对46名健康志愿者及113名乳腺肿物患者的体表皮肤进行无创红外光谱测定, 并从分子水平比较、分析了正常乳腺和有肿物乳腺体表皮肤的红外光谱特征. 结果表明, 健康志愿者乳房皮肤8个FTIR光谱测定部位的图谱趋于一致; 正常乳腺体表与有肿瘤乳腺体表的吸收峰差异明显, 而1080 cm-1处核酸相关吸收峰的变化对鉴别肿瘤的良、 恶性有重要意义.

关键词: 傅里叶变换红外光谱, 衰减全反射, 光导纤维, 乳腺癌

Abstract:

To identify Fourier transform infrared(FTIR) spectra of normal and abnormal(mass) breast skin at molecular level, infrared scanning was performed for 46 healthy volunteers and 113 inpatients with palpable breast masses. Breast surface were measured by FTIR spectrometer equipped with attenuated total reflectance(ATR) probe and infrared optical fiber. The results showed that the spectra of healthy volunteers tended to be consistent; the FTIR spectra of control, benign and malignant groups differed owing to content or configuration alterations of nucleic acids, proteins, lipids and carbohydrates, and changes in differential diagnosis of benign and malignant were predominantly observed in the 1080 cm-1 peak absorbance, commonly associated with nucleic acids.

Key words: Fourier transform infrared(FTIR) spectroscopy, Attenuated total reflectance(ATR), Optical fiber, Breast cancer

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