高等学校化学学报 ›› 2012, Vol. 33 ›› Issue (07): 1438-1443.doi: 10.3969/j.issn.0251-0790.2012.07.013

• 分析化学 • 上一篇    下一篇

CCl4 对左旋氧氟沙星超声降解的影响

魏红1, 李娟1, 李克斌2, 孙剑宇1, 赵锋2   

  1. 1. 西安理工大学西北水资源与环境生态教育部重点实验室, 西安 710048;
    2. 西北大学化学与材料科学学院, 合成与天然功能分子化学教育部重点实验室, 西安 710069
  • 收稿日期:2011-08-09 出版日期:2012-07-10 发布日期:2012-07-10
  • 通讯作者: 魏 红, 女, 博士, 副教授, 主要从事水体中有机污染控制研究. E-mail: weihong0921@xaut.edu.cn E-mail:weihong0921@xaut.edu.cn
  • 基金资助:

    国家自然科学基金(批准号: 51009115)和陕西省科技计划项目(批准号: 2010JQ5008)资助.

Effect of CCl4 on Antibiotics Levofloxacin’s Ultrasonic Degradation

WEI Hong1, LI Juan1, LI Ke-Bin2, SUN Jian-Yu1, ZHAO Feng2   

  1. 1. Key Laboratory of Northwest Water Resources, Environment and Ecology, Ministry of Education, Xi’an University of Technology, Xi’an 710048, China;
    2. Key Laboratory of Synthetic and Natural Functional Molecule Chemistry, Ministry of Education, School of Chemistry and Material Science, Northwest University, Xi’an 710069, China
  • Received:2011-08-09 Online:2012-07-10 Published:2012-07-10

摘要: 研究了CCl4对超声降解喹诺酮类抗生素左旋氧氟沙星(Levofloxacin)的影响, 考察了CCl4添加量、 超声功率、 溶液初始pH值及左旋氧氟沙星初始浓度等影响因素, 并采用HPLC和LC-MS/MS对超声降解产物进行了初步分析. 结果表明, CCl4增强了左旋氧氟沙星的超声降解, 当反应液体积为50 mL, 超声35 min时, 随着CCl4体积分数的增大(0~0.06%), 左旋氧氟沙星的降解率由1.9%增至69.2%; 超声功率为100~200 W时, 降解率随着功率的升高而增大, 功率为200~400 W时降解率有所降低; pH值对左旋氧氟沙星的超声降解影响很大, pH =7.14时容易超声降解, pH过低或过高均导致降解率显著减小; CCl4的体积分数一定时, 左旋氧氟沙星的降解率随其初始浓度的增大而降低; 左旋氧氟沙星的降解率在33~49 ℃时最大. CCl4强化超声降解左旋氧氟沙星过程主要是由·OH和一系列氯自由基参与的反应. HPLC分析发现, 降解过程中同时生成了2个产物, 并通过LC-MS/MS对其进一步鉴定.

关键词: 喹诺酮类抗生素, 左旋氧氟沙星, 超声降解, 四氯化碳

Abstract: The ultrasonic degradation of quinolone antibiotics levofloxacin in water with CCl4 enhancement was investigated. The effects of CCl4 dosage, ultrasonic power, pH value and initial concentration of levofloxacin were discussed. The products were examined by HPLC and LC-MS/MS. The results indicated that the ultrasonic degradation of levofloxacin was obviously enhanced by CCl4 addition; the degradation efficiency increased from 1.9% to 69.2% with CCl4 dosage changed from 0 to 0.06%(volume fraction). The enhancement effect was attributed to the increasing ·OH radical concentration and formation of chlorine-containing radicals in the presence of CCl4 during ultrasonic processes. Levofloxacin degradation efficiency by ultrasonic in the presence of CCl4 increased with the increasing of ultrasonic power in 100-200 W. The pH values of solution had prominent effect on levofloxacin degradation, while the initial concentration of levofloxacin had a negative effect. The temperature between 33-49 ℃ was found to be favorable to levofloxacin degradation. Moreover, HPLC analysis showed that two main by-products were simultaneously produced in the course of the ultrasonic degradation of levofloxacin in addition of CCl4, the two products were confirmed by LC-MS/MS analysis.

Key words: Quinolone antibiotics, Levofloxacin, Ultrasonic degradation, Carbon tetrachloride

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