高等学校化学学报 ›› 2012, Vol. 33 ›› Issue (04): 843.doi: 10.3969/j.issn.0251-0790.2012.04.035

• 高分子化学 • 上一篇    下一篇

具有垂直孔道的壳聚糖乳酸盐海绵的制备及体外释药模型的拟合分析

于飞1,2, 奚廷斐1,2, 张姝江3, 张志雄2, 赖琛2   

  1. 1. 温州医学院, 温州 325035;
    2. 北京大学深圳研究院, 深圳 518057;
    3. 广州医学院第一附属医院, 广州 510120
  • 收稿日期:2011-05-26 出版日期:2012-04-10 发布日期:2012-04-10
  • 作者简介:赖琛, 女, 博士, 研究员, 主要从事高分子材料及医用材料研究. E-mail: laichen1110@163.com
  • 基金资助:

    国家"九七三"项目(批准号: 2012CD933603)和深圳市科技计划项目(批准号: JC200903170498A)资助.

Preparation of Chitosan Lactate Sponges with Uniform Vertical Pores and Fitted Analysis of Release Medicine Model in vitro

YU Fei1,2, XI Ting-Fei1,2, ZHANG Shu-Jiang3, ZHANG Zhi-Xiong2, LAI Chen2   

  1. 1. Wenzhou Medical College, Wenzhou 325035, China;
    2. Shenzhen Institute of Peking University, Shenzhen 518057, China;
    3. The First Affiliated Hospital of Guangzhou Medical College, Guangzhou 510120, China
  • Received:2011-05-26 Online:2012-04-10 Published:2012-04-10
  • Supported by:

    国家"九七三"项目(批准号: 2012CD933603)和深圳市科技计划项目(批准号: JC200903170498A)资助.

摘要: 先将壳聚糖(CH)经乳酸改性制成壳聚糖乳酸盐(LCH)以改善其溶解性, 然后通过加入冰晶生长引导剂叔丁醇(TBA), 在特制的定向冷冻装置中冻结, 再经冷冻干燥后, 制成了一种圆柱形的海绵体, 其内部具有垂直方向上的孔道结构. 通过控制叔丁醇的浓度, 制备了具有不同孔径及孔隙率的海绵样品. 以红霉素为模型药物, 研究了具有自身降解溶蚀功能的LCH样品的体外释药模型, 结果表明, LCH样品的释药过程主要分为基体溶蚀控释和药物后扩散2个阶段. 其中基体控释阶段符合Couarraze释药模型.

关键词: 壳聚糖乳酸盐, 叔丁醇, 溶蚀控释, 体外释药拟合分析

Abstract: Chitosan lactate(LCH) was obtained by reacting with lactic acid based on chitosan(CH). The products were found to be superior to original chitosan as far as water solubility was concerned. With the structure-directing agent tertiary butyl alcohol(TBA) in the vertical temperature controlled device, uniform and vertical pores structure in sponges were obtained upon freeze-drying. Different diameter form sponge samples were made by controlling the concentration of TBA. Then, drug delivering model of sponges samples with degradation and dissolution function was studied with erythromycin as model drug in vitro. The results demonstrate that drug delivering process of sponge samples is divided into two stages: matrix dissolution controlled-release stage and drug after-diffusion stage. Matrix dissolution controlled-release stage is very good to fit the couarraze drug delivering model.

Key words: Chitosan lactate(LCD), Tertiary butyl alcohol(TBA), Dissolution controlled-release, Fitted analysis of release medicine model in vitro

中图分类号: 

TrendMD: