Studies on the Allyl Protection of Hydroxyl Group in Nucleosides

Chem. J. Chinese Universities ›› 1998, Vol. 19 ›› Issue (5): 728.

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Studies on the Allyl Protection of Hydroxyl Group in Nucleosides

ZHOU Ying, ZHANG Liang-Ren, ZHANG Li-He

National Laboratory of Natural and Biomimetic Drugs, Beijing Medical University, Beijing, 100083

Received:1997-05-26 Online:1998-05-24 Published:1998-05-24

Abstract

Abstract: The possibility of allyl as the protection group of the hydroxyls in nucleosides was studied. Allyl bromide can react with thymidine and adenosine in the presence of NaOH to give O-allyl protected nucleosides in good yield. PdCl₂ can be used as a reagent for the deprotection. It was found that PdCl₂ can selectively deprotect the p-methoxytrityl, di-p-methoxytrityl or both of the p-methoxytrityl, di-p-methoxytrityl and allyl group.

Key words: Allyl, p-Methoxytrityl, Di-p-methoxytrityl, PdCl₂, Hydroxyls of ribose

CLC Number:

O622

TrendMD:

ZHOU Ying, ZHANG Liang-Ren, ZHANG Li-He . Studies on the Allyl Protection of Hydroxyl Group in Nucleosides[J]. Chem. J. Chinese Universities, 1998, 19(5): 728.

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Studies on the Allyl Protection of Hydroxyl Group in Nucleosides

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