Synthesis of Fluorescent Nanoparticle Sensors for Simultaneous Determination of Double Targets

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Synthesis of Fluorescent Nanoparticle Sensors for Simultaneous Determination of Double Targets

FEI Yan-Qun¹, LUO Gui-Min¹, FENG Guo-Dong², FEI Qiang², CHEN Huan-Wen², LIANG Xue-Kai², ZHAO Xiao-Jun³*, HUAN Yan-Fu^1,2*

1. Key Laboratory for Molecular Enzymology & Engineering, Ministry of Education, Jilin University, Changchun 130021, China;
2. College of Chemistry, Jilin University, Changchun 130012, China;
3. Department of Chemistry, University of North Dakota, Grand Forks 58203, USA

Received:2007-09-21 Revised:1900-01-01 Online:2008-01-10 Published:2008-01-10
Contact: HUAN Yan-Fu,ZHAO Xiao-Jun

Abstract

Abstract: New fluorescent silica nanoparticles for sensors simultaneous determination of double targets were synthesized via a reverse microemulsion method based on the fluorescence resonance energy transfer(FRET). Nanoparticle A was doped with a dye complex which consisted of two dye molecules, fluorescein and tetramethylrhodamine. These dye molecules were first linked with avidin and biotin, respectively. They then formed a stable dye complex through avidin-biotin bridge within the distance of FRET. Nanoparticle B was doped with fluorescein only. As a result of this combination, the nanoparticles emit double wavelengths when a single excitation wavelength is used. The results show that the fluorescent nanoparticles are promising fluorescent labeling reagents for the sensitive detection of double targets.

Key words: Nanoparticle, Double targets, Simultaneous determination, Fluorescence resonance energy transfer

CLC Number:

O657.34

TrendMD:

FEI Yan-Qun¹, LUO Gui-Min¹, FENG Guo-Dong², FEI Qiang², CHEN Huan-Wen², LIANG Xue-Kai², ZHAO Xiao-Jun³*, HUAN Yan-Fu^1,2*. Synthesis of Fluorescent Nanoparticle Sensors for Simultaneous Determination of Double Targets[J]. Chem. J. Chinese Universities, doi: .

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Synthesis of Fluorescent Nanoparticle Sensors for Simultaneous Determination of Double Targets

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