Synthesis and Biological Activities of 1-Alkyl-2-methyl-4 (5)-nitroimidazole Derivatives

Abstract

Abstract: Seven α,ω-di-[2-methyl-4-nitroimidazolyl)]alkanes and twenty 1-alkyl-2-methyl-4-nitroimidazoles were synthesized with solid-liquid phase-transfer catalytic method. The yield for the most of compounds is more than 80% except a few compounds. The structures of the compounds were confirmed by IR,¹H NMRand elementary analysis. The preliminary biological activity test shows that some of the compounds have certain anti-inflammatory,antibacterial, analgesic, sedative or anticerebral anoxia activities.

Key words: 2-Methyl-4-nitroimidazole, Solid-liquid phase transfer catalysis, Biological activity

CLC Number:

O626.23

TrendMD:

LI Run-Tao, CAO Sheng-Li, SUN Wan-Fu, CAI Meng-Shen . Synthesis and Biological Activities of 1-Alkyl-2-methyl-4 (5)-nitroimidazole Derivatives[J]. Chem. J. Chinese Universities, 1997, 18(8): 1325.

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Synthesis and Biological Activities of 1-Alkyl-2-methyl-4 (5)-nitroimidazole Derivatives

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