Synthesis and Biological Activities of 1,2,3-Thiadiazol-4-acetamide(Acetmorpholide) Derivatives

Chem. J. Chinese Universities

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Synthesis and Biological Activities of 1,2,3-Thiadiazol-4-acetamide(Acetmorpholide) Derivatives

DONG Wei-Li¹, YAO Hong-Wei¹, WANG Feng-Long², LI Zheng-Ming¹, SHEN Li-Li², QIAN Yu-Mei², ZHAO Wei-Guang¹*

1. National Key Laboratory of Elemento-Organic Chemistry, National Pesticide Engineering Resarch Center, Nankai University, Tianjin 300071, China;
2. Tobacco Research Institute of CAAS, Qingdao 266101, China

Received:2006-12-14 Revised:1900-01-01 Online:2007-09-10 Published:2007-09-10
Contact: ZHAO Wei-Guang

Abstract

Abstract: In the investigation of new agrochemicals, we found 1,2,3-thiadiazole derivatives with good biological activities, had received only limited attention, but commercial pesticides containing 1,2,3-thiadiazole often possess a unique active mechanism, such as TDZ, BTH and tiadinil. We became interested in making 1,2,3-thiadiazoleacetamides, analogues of three commercial pesticides. In order to search for novel 1,2,3-thiadiazole derivatives with high activities, we designed and synthesized a series of novel 1,2,3-thiadiazole-4-acetamide(acetmorpholide)derivatives using diketene as the starting materials. Their structures were identified by means of elemental analysis, IR, ¹H NMR and MS spectra. The results of the preliminary biological activity tests show that some of the compounds exhibit a better anti-TMV activity, plant growth regulator activity and fungicidal activity.

Key words: 1,2,3-Thiadiazole, Acetamide, Biological activity

CLC Number:

O626

TrendMD:

DONG Wei-Li¹, YAO Hong-Wei¹, WANG Feng-Long², LI Zheng-Ming¹, SHEN Li-Li², QIAN Yu-Mei², ZHAO Wei-Guang¹*. Synthesis and Biological Activities of 1,2,3-Thiadiazol-4-acetamide(Acetmorpholide) Derivatives[J]. Chem. J. Chinese Universities, doi: .

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Synthesis and Biological Activities of 1,2,3-Thiadiazol-4-acetamide(Acetmorpholide) Derivatives

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