Computer Simulation of Human Iodothyronine Deiodinase Single-chain Antibody

Chem. J. Chinese Universities ›› 2002, Vol. 23 ›› Issue (6): 1065.

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Computer Simulation of Human Iodothyronine Deiodinase Single-chain Antibody

LIN Feng², ZHANG Wei³, CHEN Mo¹, DING Lan¹, LIU Lan-Ying², XU Xiao-Jie-ZHAOD a-Qing³, NI Jia-Zuan¹

1. Laboratory of Rare Earth Chemistry and Physics, Changchun Insitute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China;
2. College of Life Science, Jilin University, Chang chun 130023, China;
3. College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China

Received:2001-03-02 Online:2002-06-24 Published:2002-06-24

Abstract

Abstract: Iodothyronine plays a major role in growth, basic metabolism and organ formation. It has an extremely limited source in the body. In this thesis, we designed iodothyronine(T4) as hapten. Then a single chain antibody displayed on phange was obtained from a human phage displaying a single chain antibody library. The specific genes of E3 was subcloned in P-5E vector. According to its amino acid sequences, we simulate its three-dimention structure by computer. It has never been reported in PDB.

Key words: Iodothyronine deiodinase, Single-chain antibody, Computer simulation

CLC Number:

R921.61

TrendMD:

LIN Feng, ZHANG Wei, CHEN Mo, DING Lan, LIU Lan-Ying, XU Xiao-Jie-ZHAOD a-Qing, NI Jia-Zuan . Computer Simulation of Human Iodothyronine Deiodinase Single-chain Antibody[J]. Chem. J. Chinese Universities, 2002, 23(6): 1065.

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Computer Simulation of Human Iodothyronine Deiodinase Single-chain Antibody

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