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One New Flavanoid and Anti-HIV Active Constituents from Boussingaultia gracilis Miers var. pseudobaselloides Bailey

GU Qiong1,4, MA Yun-Bao1,3, ZHANG Xue-Mei1,3, WANG Rui-Rui2,4, ZHOU Jun1,3, ZHENG Yong-Tang2,3, CHEN Ji-Jun1,3*   

    1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China;
    2. Laboratory of Molecular Immunopharmacology, Key Laboratory of Animal Models and Human Diseases Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China;
    3. The Joint-Laboratory of Antiviral Natural Medicines, Kunming Branch, Chinese Academy of Sciences, Kunming 650204, China;
    4. Graduate School of the Chinese Academy of Sciences, Beijing 100039, China
  • Received:2006-09-25 Revised:1900-01-01 Online:2007-08-10 Published:2007-08-10
  • Contact: CHEN Ji-Jun

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Abstract: Boussingaultia gracilis Miers var. pseudobaselloides Bailey(Basellaceae) is a folk medicine used as an analgesic and supplements, only a few research was reported on the chemical constituents of this plant. This paper presented its chemical and anti-HIV active constituents. By column chromatography(Silica and Sephadex LH-20 gel) methods, two flavanols and four flavones were isolated from the 70%(volume fraction) ethanol extract. Based on extensive spectral analysis(UV, IR, MS and 1D, 2D NMR), compounds 1—6 were identified as bougracol A(1), 4,7-dihydroxy-5-methoxy-8-methyl-6-formyl-flavane(2), 7-O-methylunonal(3), 5,7-dihydroxy-6,8-dimethyl-2-phenyl-4H-1-benzopyran-4-one(4), desmosflavone(5) and demethoxymatteucinol(6). Among them, compound 1, a new flavan-diols, was deduced to be 7-hydroxy-5-methoxy-8-methyl-6-formyl-flavan-3,4-diols, and compounds 2—6 were firstly obtained from this plant. Anti-HIV assay suggests that compounds 1, 2, 5, 6 showed weak anti-HIV activities with EC50 values of 45.09, 48.73, 55.47 and 82.75 μmol/L, and TI values of 1.41, 1.20, 7.15 and >8.51, respectively.

Key words: Boussingaultia gracilis Miers var. pseudobaselloides Bailey, Boussingol A, Flavanoid, Anti-HIV activity

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