Synthesis Property Characterization of Coreshell Co@SiO2 Magnetic Nanoparticle and Its Biomedical Applications to Cell Separation and Cell Chip

Chem. J. Chinese Universities

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Synthesis Property Characterization of Coreshell Co@SiO₂ Magnetic Nanoparticle and Its Biomedical Applications to Cell Separation and Cell Chip

GUO Xiao-Ying¹, WANG Yong-Ning², GU Lin-Gang³, HE Yan-Feng⁴, ZHANG Chun-Xiu¹, TANG Zu-Ming¹, LU Zu-Hong¹

1. State Key Laboratory of Molecular and Biomolecular Electronics, Southeast University, Nanjing 210096, China;
2. Technical Institute of Physical and Chemistry, Chinese Academy of Sciences, Beijing 100080, China;
3. Division of the Criminal Investigation, Department of Jiangsu Provincial Public Security, Nanjing 210024, China;
4. College of Public Health, Southeast University, Nanjing 210009, China

Received:2005-09-21 Revised:1900-01-01 Online:2006-09-10 Published:2006-09-10
Contact: LU Zu-Hong

Abstract

Abstract: In this paper, Co@SiO₂ nanoparticles with the apparent coreshell magnetic nanostructure were synthesized by reducing and hydrolysis in aqueous solutions. The TEM, VSM, SEM, and the confocal fluorescence microscope were utilized to characterize the morphology, size, magnetism of the Co@SiO₂ nanoparticles, and the coreshell materials were applied to the cell separation, immunophenotyping of leukemias and lymphomas diagnostics chip, in which strenuous procedures were omitted by the use of the magnetic coreshell nanoparticles, and separation. These core-shell nanoparticles were proved to have obvious cores and shell, and the cores have strong magnetism, and the shell protected these nanosized metal particles from coagulation due to anistropic dipolar attraction and oxidation very well. However this method could not limited the original cores below the size of 10 nm, which is the critical size of superparamagnetisizm, as a result coagulation due to remanent magnetism limited this core-shell particles from further applications in bioseparation.

Key words: Core-shell, Magnetic nanoparticle, Immunophenotyping of leukemias and lymphomas, Cell separation

CLC Number:

O647.2

TrendMD:

GUO Xiao-Ying¹, WANG Yong-Ning², GU Lin-Gang³, HE Yan-Feng⁴, ZHANG Chun-Xiu¹, TANG Zu-Ming¹, LU Zu-Hong¹
. Synthesis Property Characterization of Coreshell Co@SiO₂ Magnetic Nanoparticle and Its Biomedical Applications to Cell Separation and Cell Chip[J]. Chem. J. Chinese Universities, doi: .

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Synthesis Property Characterization of Coreshell Co@SiO₂ Magnetic Nanoparticle and Its Biomedical Applications to Cell Separation and Cell Chip

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