Novel Approach for Quality Evaluation of Traditional Chinese Medicine Based on Integrated Selected-ion Chromatograms

Chem. J. Chinese Universities ›› 2011, Vol. 32 ›› Issue (11): 2515.

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Novel Approach for Quality Evaluation of Traditional Chinese Medicine Based on Integrated Selected-ion Chromatograms

ZHANG Yu-Feng, FAN Xiao-Hui, QU Hai-Bin*

Pharmaceutical Informatics Institute, Zhejiang University, Hangzhou 310058, China

Received:2010-12-03 Revised:2011-03-25 Online:2011-11-10 Published:2011-10-14
Contact: QU Hai-Bin E-mail:quhb@zju.edu.cn
Supported by:
国家重大科技专项“重大新药创制”项目(批准号: 2009ZX09313-036, 2009ZX09304-002)和国家自然科学基金(批准号: 81001687)资助.

Abstract

Abstract: A liquid chromatography-mass spectrometry(LC-MS) based fingerprinting method was developed to study the Shuangdan extracts prepared by Danshen and Danpi from different habits; the two-way LC-MS datasets were converted to one-way integrated selected-ion chromatograms(ISICs) by our homely-made software and their discriminate power together with total ion chromatograms(TICs) and retention time corrected TICs were evaluated by principle component analysis. The results showed that ISICs surpassed TICs and retention time corrected TICs to separate herbal extracts from different places of produce. This transformation approach is rather fast and compatible with large datasets. The ISICs having more chemical information than TICs could be directly exported to statistical softwares for further analysis, whose retention times do not need to be corrected.

Key words: Integrated selected-ion chromatogram(ISIC), Shuangdan formula, Liquid chromatography-mass spectrometry(LC-MS)

CLC Number:

TrendMD:

ZHANG Yu-Feng, FAN Xiao-Hui, QU Hai-Bin*. Novel Approach for Quality Evaluation of Traditional Chinese Medicine Based on Integrated Selected-ion Chromatograms[J]. Chem. J. Chinese Universities, 2011, 32(11): 2515.

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Novel Approach for Quality Evaluation of Traditional Chinese Medicine Based on Integrated Selected-ion Chromatograms

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