Chem. J. Chinese Universities ›› 2010, Vol. 31 ›› Issue (12): 2313.

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Effect of Polyaspartic Acid Modification on Stability and MRI Enhancement of Magnetic Iron Oxide Nanoparticles

SUN Lin2,LIU GuiFeng1,ZHUANG JiaQi2,ZHANG HuiMao1*,YANG WenSheng2   

  1. 1. China-Japan Union Hospital, Jilin University, Changchun 130033, China
    2. College of Chemistry, Jilin University, Changchun 130012, China
  • Received:2010-08-31 Revised:2010-10-12 Online:2010-12-10 Published:2010-12-06
  • Contact: ZHANG HuiMao E-mail:HuiMaoZhanglinda@163.com
  • About author:张惠茅, 女, 副主任医师, 主要从事放射影像学研究. E-mail: HuiMaoZhanglinda@163.com
  • Supported by:

    国家自然科学基金(批准号: 50902058, 50825202)资助.

Abstract:

Polyaspartic acid (PSAP) was employed to modify the surface of superparamagnetic iron oxide (SPIO). The colloidal stability of SPIO could be adjusted by the amount of PSAP used and the modified SPIO showed improved stability under physiological condition. Magnetic resonance imaging (MRI) experiments of rabbit brain demonstrated that the PSAP modified SPIO can be well dispersed into the brain tissue, resulting in enhanced contrast of the MRI images.

Key words: Superparamagnetic iron oxide, Polyaspartic acid, Magnetic resonance imaging, Contrast agent

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