Detection of the Thyroid Tumor via Percutaneous,in vivo and in vitro Examination Using FT-mid-IR Fiber Optics Spectroscopy

Chem. J. Chinese Universities ›› 2005, Vol. 26 ›› Issue (12): 2227.

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Detection of the Thyroid Tumor via Percutaneous,in vivo and in vitro Examination Using FT-mid-IR Fiber Optics Spectroscopy

XU Yi-Zhuang^1*,ZHAO Ying²,XU Zhi³,YANG Li-Min⁴,LIU Yu-Feng¹,LING Xiao-Feng³,ZHANG Neng-Wei⁵,WANG Li-Xin³,WANG Bing-Bing¹,MENG Tao²,ZHANG Yuan-Fu¹,WENG Shi-Fu¹, ZHOU Xiao-Si³,XU Duan-Fu²,WU Jin-Guang¹

1. State Key Laboratory of Rare Earth Materials and Applications,College of Chemistry and Molecular Engineering,Peking University,Beijing 100871,China; 2. Institute of Chemistry,Chinese Academy of Sciences,Beijing 100080,China; 3. The Third Hospital,Peking University,Beijing 100083,China; 4. Institute of Heavy Ions,School of Physics,Peking University,Beijing 100871,China; 5. Beijing Railway General Hospital,Beijing 100038,China

Received:2005-08-01 Online:1905-03-14 Published:1905-03-14
Contact: XU Yi-Zhuang;E-mail:xyz@pku.edu.cn

Abstract

Abstract:

In the present paper,FT-mid-IR fiber optics spectroscopy was used to determine the thyroid tumor. A modified WQF-500 FTIR spectrometer with MCT detector and mid-IR fiber optics ATR accessory was used in this work. Percutaneous examination of the skin overlying the thyroid tumor was performed on five patients,in vivo detection and in vitro measurement of six patients in operation room was also carried out. The experimental data indicate that malignant and benign thyroid tumor could be distinguished from the spectra of percutaneous examination,the in vivo measurement and freshly resected thyroid tissues. The relative intensity and peak position of the IR bands in the region of 1 700-1 500 cm-1(amide Ⅰ and amide Ⅱ),1 480-1 400 cm-1,and 1 320-1 200 cm-1 are reliable spectral marker or indexes for tumor detection. These results demonstrate that FT-mid-IR fiber optics spectroscopy exhibits prospect to develop a novel non-invasive method for thyroid tumor detection.

Key words: FTIR; Mid-IR fiber optics; Thyroid tumor; Detection

CLC Number:

O657.33

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XU Yi-Zhuang, ZHAO Ying, XU Zhi, YANG Li-Min, LIU Yu-Feng, LING Xiao-Feng, ZHANG Neng-Wei, WANG Li-Xin, WANG Bing-Bing, MENG Tao, ZHANG Yuan-Fu, WENG Shi-Fu, ZHOU Xiao-Si, XU Duan-Fu, WU Jin-Guang. Detection of the Thyroid Tumor via Percutaneous,in vivo and in vitro Examination Using FT-mid-IR Fiber Optics Spectroscopy[J]. Chem. J. Chinese Universities, 2005, 26(12): 2227.

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Detection of the Thyroid Tumor via Percutaneous,in vivo and in vitro Examination Using FT-mid-IR Fiber Optics Spectroscopy

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