Effects of La 3+ on Transient Outward K+ and Delayed Rectifier K+ Currents Kinetics in Hippocampal Neurons of Rat

Chem. J. Chinese Universities ›› 2006, Vol. 27 ›› Issue (1): 13.

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Effects of La ³⁺ on Transient Outward K⁺ and Delayed Rectifier K+ Currents Kinetics in Hippocampal Neurons of Rat

DU Hui-Zhi, YANG Pin

Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Molecular Science, Shanxi University, Taiyuan 030006, China

Received:2004-12-17 Online:2006-01-10 Published:2006-01-10
Contact: YANG Pin,E-mai: yangpin@sxu.edu.cn

Abstract

Abstract:

Using the whole cell patchclamp technique, the effects of La ³⁺ on transient outward K⁺ and delayed rectifier K⁺ currents kinetics were studied in acutely isolated rat hippocampal neurons. The results show that La ³⁺ in the external solution inhibited IA(K⁺current) in a concentration and voltage-dependent manner. The La ³⁺ concentration of 10^-5 mol/L could significantly affect Vh of the activation curve and inactivation curve of IA, respectively, but the k was not changed. La ³⁺ in the external solution did not affect IK(platform current) and the activation curve. These may contribute to abnormity of the central nervous system by La ³⁺ .

Key words: Patch-clamp technique; Hippocampal neurons; La ³⁺

CLC Number:

O614.33

TrendMD:

DU Hui-Zhi, YANG Pin. Effects of La ³⁺ on Transient Outward K⁺ and Delayed Rectifier K+ Currents Kinetics in Hippocampal Neurons of Rat[J]. Chem. J. Chinese Universities, 2006, 27(1): 13.

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Effects of La ³⁺ on Transient Outward K⁺ and Delayed Rectifier K+ Currents Kinetics in Hippocampal Neurons of Rat

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