Synthesis, Characterization and Relaxation Property of Oligomeric Gadolinium Complex Based on Amide Derivetives of DTPA

doi:10.3969/j.issn.0251-0790.2012.04.000

Chem. J. Chinese Universities ›› 2012, Vol. 33 ›› Issue (04): 663.doi: 10.3969/j.issn.0251-0790.2012.04.000

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Synthesis, Characterization and Relaxation Property of Oligomeric Gadolinium Complex Based on Amide Derivetives of DTPA

HAO Zhi-Feng¹, WU Ya-Hong¹, WANG Zhao-Yang², HUANG Zhuo-Liang¹, YU Jian¹, YU Lin¹

1. Faculty of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, China;
2. School of Chemistry and Environment, South China Normal University, Guangzhou 510006, China

Received:2011-08-16 Online:2012-04-10 Published:2012-04-10
Supported by:
国家自然科学基金(批准号: 21101032)和广东省自然科学基金(批准号: 06021469)资助.

Abstract

Abstract: An oligomeric complex was prepared via assembly reaction of oligomeric diethylenetriamine-N,N′-di(acetyl-p-aniline)-N,N′,N″-triacetic acid [H₃L]_n with GdCl₃in DMF-H₂O mixed solvent. The composition unit of the complex was confirmed to be [GdL(H₂O)]·4H₂O after characterized by Fourier transform infrared spectroscope(FTIR), elemental analysis, ¹H NMR, thermal gravimetric and differential thermal analysis(TG-DTA), which showed that every unit of the oligomeric ligand was coordinated to one metal ion. The longitudinal relaxivity time T₁ of oligomeric Gd complex and Gd-DTPA(DTPA is diethylene triamine pentaacetic acid ) were tested by inversion recovery. The results indicated that the relaxivity R₁ of the oligomeric Gd complex was 8.526 mmol·L^-1·s^-1, which was greater than small molecular weight complex Gd-DTPA(4.370 mmol·L^-1·s^-1).

Key words: Acylated polymerization, Oligomeric complex, Gd(Ⅲ) complex, Relaxation property

CLC Number:

O614.33

TrendMD:

HAO Zhi-Feng, WU Ya-Hong, WANG Zhao-Yang, HUANG Zhuo-Liang, YU Jian, YU Lin. Synthesis, Characterization and Relaxation Property of Oligomeric Gadolinium Complex Based on Amide Derivetives of DTPA[J]. Chem. J. Chinese Universities, 2012, 33(04): 663.

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Synthesis, Characterization and Relaxation Property of Oligomeric Gadolinium Complex Based on Amide Derivetives of DTPA

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