Polydopamine-coated Fe3O4/methylprednisolone/cyclophosphamide Superparticles for the Magnetic Targeting Treatment of Pulmonary Fibrosis

doi:10.7503/cjcu20210438

Abstract

Abstract:

Pulmonary fibrosis is a serious fatal disease and it exists clinical adverse effects for the conventional combined treatment using methylprednisolone（MPS） and cyclophosphamide（CTX）. In this work， polydopamine（PDA）-coated Fe₃O₄/MPS/CTX superparticles（Fe₃O₄/MPS/CTX@PDA SPs） were prepared to reduce the adverse effects of drugs， which provide a magnetic targeting strategy for the therapy of pulmonary fibrosis. In the experiment， Fe₃O₄ SPs were foremost prepared from Fe₃O₄ nanoparticles using oil-in-water droplets as the templates， and followed by coating PDA shell in the presence of MPS and CTX to produce Fe₃O₄/MPS/CTX@PDA SPs. Systematically characterizations proved the successful preparation of Fe₃O₄/MPS/CTX@PDA SPs， and revealed the stability， magnetism， drug loading and release. The cytotoxicity was further discussed in vitro， and an animal model was built to confirm the magnetic targeting of Fe₃O₄/MPS/CTX@PDA SPs in vivo.

Key words: Polydopamine, Fe₃O₄ nanoparticles, Superparticles, Pulmonary fibrosis, Magnetic targeting

CLC Number:

O631

TrendMD:

SUN Qirui, ZHAO Nan, LIU Shuwei, XIN Hua, ZHANG Hao, ZHANG Lening. Polydopamine-coated Fe₃O₄/methylprednisolone/cyclophosphamide Superparticles for the Magnetic Targeting Treatment of Pulmonary Fibrosis[J]. Chem. J. Chinese Universities, 2021, 42(10): 3225.

Figures/Tables 8

References 20

1	Martinez F. J.， Collard H. R.， Pardo A.， Raghu G.， Richeldi L.， Selman M.， Swigris J. J.， Taniguchi H.， Wells A. U.， Nat. Rev. Dis. Primers， 2017， 3， 17074
2	Homma S.， Bando M.， Azuma A.， Sakamoto S.， Sugino K.， Ishii Y.， Izumi S.， Inase N.， Inoue Y.， Ebina M.， Ogura T.， Kishi K.， Kishaba T.， Kido T.， Gemma A.， Goto Y.， Sasaki S.， Johkoh T.， Suda T.， Takahashi K.， Takahashi H.， Taguchi Y.， Date H.， Taniguchi H.， Nakayama T.， Nishioka Y.， Hasegawa Y.， Hattori N.， Fukuoka J.， Miyamoto A.， Mukae H.， Yokoyama A.， Yoshino I.， Watanabe K.， Respiratory Investigation， 2018， 56（4）， 268—291
3	Richeldi L.， Davies H. R. H. R.， Spagnolo P.， Luppi F.， Cochrane Database of Systematic Reviews， 2003，（3）， CD002880
4	Davies H. R. H. R.， Richeldi L.， Walters E. H.， Cochrane Database of Systematic Reviews， 2003，（2）， CD003134
5	Raghu G.， Anstrom K. J.， King T. E.， Lasky J. A.， Martinez F. J.， N. Engl. J. Med.， 2012， 366（21）， 1968—1977
6	Li R. Q.， Zheng D. W.， Han Z. Y.， Xie T. Q.， Zhang C.， An J. X.， Xu R.， Sun Y. X.， Zhang X. Z.， Mater. Today， 2020， 40， 91—100
7	Jiang Q.， Wang K.， Zhang X. Y.， Ouyang B. S.， Liu H. X.， Pang Z. Q.， Yang W. L.， Small， 2020， 16（22）， 2001704
8	Zanganeh S.， Hutter G.， Spitler R.， Lenkov O.， Mahmoudi M.， Shaw A.， Pajarinen J. S.， Nejadnik H.， Goodman S.， Moseley M.， Coussens L. M.， Daldrup⁃Link H. E.， Nat. Nanotechnol.， 2016， 11（9）， 986—994
9	Wang Q.， Xiao J.， Su Y. H.， Huang J. W.， Li J. H.， Qiu L. G.， Zhan M. X.， He X.， Yuan W. Z.， Li Y.， Polym. Chem.， 2021， 12（14）， 2132—2140
10	Xia Y. S.， Tang Z. Y.， Chem. Commun.， 2012， 48（51）， 6320—6336
11	Zhuang J.， Wu H.， Yang Y.， Cao Y. C.， Angew. Chem. Int. Ed.， 2008， 47（12）， 2208—2212
12	Zheng R.， Wang S.， Tian Y.， Jiang X.， Fu D.， Shen S.， Yang W.， ACS. Appl. Mater. Interfaces， 2015， 7（29）， 15876—15884
13	Liu Y. L.， Ai K. L.， Lu L. H.， Chem. Rev.， 2014， 114（9）， 5057—5115
14	Sun S. H.， Zeng H.， J. Am. Chem. Soc.， 2002， 124（28）， 8204—8205
15	Bai F.， Wang D.， Huo Z.， Chem W.， Liu L.， Liang X.， Chen C.， Wang X.， Peng Q.， Li Y.， Angew. Chem. Int. Ed.， 2007， 46（35）， 6650—6653
16	Lin L. S.， Cong Z. X.， Cao J. B.， Ke K. M.， Peng Q. L.， Gao J.， Yang H. H.， Liu G.， Chen X.， ACSNano， 2014， 8（4）， 3876—3883
17	Zhang X.， Xu X. W.， Li T. T.， Lin M.， Lin X. Y.， Zhang H.， Sun H. C.， Yang B.， ACS. Appl. Mater. Interfaces， 2014， 6（16）， 14552—14561
18	Song Z. Q.， Gong B. J.， Wang L.， Feng J.， Wang B.， Yan H. J.， Li Z. M.， Sun H. C.， Chem. J. Chinese Universities， 2019， 40（1）， 166—172（宋子琦，公柏娟，王璐，冯婧，王博，闫弘静，李志民，孙宏晨. 高等学校化学学报， 2019， 40（1）， 166—172）
19	Li J.， Wang W. J.， Zhao L.， Rong L.， Lan S. J.， Sun H. C.， Zhang H.， Yang B.， ACS. Appl. Mater. Interfaces， 2015， 7（29）， 11613—11623
20	Aiello C.， Andreozzi P.， La Mesa C.， Risuleo G.， Colloids and Surfaces B： Biointerfaces，2010， 78（2）， 149—154

[1]	YU Pengdong, GUAN Xinghua, WANG Dongdong, XIN Zhirong, SHI Qiang, YIN Jinghua. Preparation and Properties of Novel Optical and Thermal Dual Response Shape Memory Polymers [J]. Chem. J. Chinese Universities, 2022, 43(6): 20220085.
[2]	WU Fengren,LIU Yongjia,LU Xuemin,ZHU Bangshang. Controllable Preparation of Polydopamine Modified Gold Nanoflowers and Its Application in Photothermal Therapy ^† [J]. Chem. J. Chinese Universities, 2020, 41(3): 465.
[3]	ZHANG Xinyu, WANG Hong, FANG Yun, FAN Ye. Stimuli-responsive Fe₃O₄ Nanoparticle Modified by Conjugated Linoleic Acid [J]. Chem. J. Chinese Universities, 2020, 41(11): 2519.
[4]	LIU Yun, LI Ting, WANG Yang, DONG Weifu. Preparation of Multi-scale Superhydrophobic Cotton/Polydopamine/Silica Composite for Selective Oil Absorption [J]. Chem. J. Chinese Universities, 2019, 40(8): 1775.
[5]	WANG Xiaohui, WANG Kexin, LIU Junping, HONG Xia. Mesoporous-structure Enhanced Photothermal Effect of Fe₃O₄ Superparticles@mesoporous Silica [J]. Chem. J. Chinese Universities, 2019, 40(8): 1586.
[6]	XIONG Zhengrong,DONG Li,LIU Xiangdong,YANG Yuming. Preparation and Properties Characterization of PDA/PVDF UV Shielding Composite Membranes [J]. Chem. J. Chinese Universities, 2019, 40(4): 849.
[7]	YANG Shuting, LI Qianhui, FAN Yuchang, WANG Qiuxian, DU Ting, YUE Hongyun. Li₄Ti₅O₁₂ Modification by Bifunctional Bionic Membrane as Anode Materials for Lithium-ion Batteries^† [J]. Chem. J. Chinese Universities, 2018, 39(11): 2513.
[8]	YANG Yuxiang, LIU Yicheng, ZHAO Min, YUAN Hongming, YAO Pingping, HUANG Yan, NI Chaoying. Thermal Reduation Preparation of Co²⁺/Dy³⁺ Doped Cubic Fe₃O₄ and Their Magnetic Targeting Retention^† [J]. Chem. J. Chinese Universities, 2017, 38(10): 1709.
[9]	LIU Yuwei, GUO Zhuo. Polydopamine-doxorubicin Colloidal Nanoparticles for Chemo-Photothermal Synergistic Therapy Against Cancer Cell^† [J]. Chem. J. Chinese Universities, 2015, 36(7): 1389.
[10]	MA Lina, LIU Fuyao, GAO Jiaxue, WANG Zhenxin. Polydopamine Nanoparticle-based Fluorescence Resonance Energy Transfer Assay for microRNA Detection^† [J]. Chem. J. Chinese Universities, 2015, 36(6): 1061.
[11]	WANG Yan, WANG Xiao-Ying, LV Yan-Yun, XU Wen-Bin, GUO Yi, XU Li. Preparation of Magnetic Drug Carriers with Evodiamine and Fe₃O₄ Nanoparticles Co-encapsulated [J]. Chem. J. Chinese Universities, 2013, 34(12): 2866.
[12]	XU Jie, ZHAO Man, HOU Wan-Guo. Synthesis and Characterization of MgFe₂O₄@(TF-LDHs) Magnetic Nanocomposites [J]. Chem. J. Chinese Universities, 2012, 33(12): 2750.
[13]	ZHAO Man, XU Jie, HOU Wan-Guo. Synthesis and Sustained Release Property of Fe₃O₄@(TF-LDHs) Nanocomposites [J]. Chem. J. Chinese Universities, 2012, 33(07): 1572.
[14]	TAN Yu-Mo, ZHENG Ya-Ping, LAN Lan. Preparation and Characterization of Solvent-free Fe₃O₄ Nanofluids [J]. Chem. J. Chinese Universities, 2012, 33(01): 206.
[15]	SUN Zhong-Xi*; GUO Shu-Yun. Surface Acid-base Properties of Magnetite Nanoparticles [J]. Chem. J. Chinese Universities, 2006, 27(7): 1351.

Polydopamine-coated Fe₃O₄/methylprednisolone/cyclophosphamide Superparticles for the Magnetic Targeting Treatment of Pulmonary Fibrosis

RichHTML

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

Figures/Tables 8

References 20

Related Articles 15

Recommended Articles

Metrics

Comments