Abstract: Resveratrol bovine serum albumin nanoparticles(RES-BSANP) were synthesized by desolvation. HPLC and Atomic force microscopy(AFM) were employed to study the shape, mean size and particle distribution of RES-BSANP. MTT was used to detect the effects of RES and RES-BSANP on the growth rate of cell SKOV3 at various concentration of them, and flow cytometry(FCM) was applied to assaying the cell cycle and cell apoptosis of cells SKOV3. The results show that RES-BSANP are slick and uniformity, the average diameter of RES-BSANP is about 400—500 nm, drug loading is about 4.077 mg/12 mg, entrapment efficiency is 33.97％. MTT test shows the growth of SKOV3 can be significantly inhibited by RES and RES-BSANP in dose-dependence manner, while RES-BSANP is superior to RES at concentrations of 60, 100, 200 μmol/L(P<0.05). FCM test shows RES-BSANP make cells SKOV3 be in S phase and the apoptosis of cells SKOV3 more significant compared with RES. Therefore, RES-BSANP appears to be a very promising drug for anti-proliferation on human ovarian carcinoma.

Key words: Resveratrol(RES), Bovine serum albumin(BSA), Resveratrol bovine serum albumin nanoparticles(RES-BSANP)