Production Mechanism Study of Singlet Oxygen in Copper Ion-Catalyzed Curcumin Using Fluorimetric Method and Its Determination in the Presence of Superoxide Anion Radical

Chem. J. Chinese Universities

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Production Mechanism Study of Singlet Oxygen in Copper Ion-Catalyzed Curcumin Using Fluorimetric Method and Its Determination in the Presence of Superoxide Anion Radical

LÜ Qing-Luan, ZHANG Miao, YUE Ning-Ning, GONG Bin, WANG Huai-You^*

College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan 250014, China

Received:2008-10-09 Revised:1900-01-01 Online:2009-03-10 Published:2009-03-10
Contact: WANG Huai-You

Abstract

Abstract: The production mechanism of singlet oxygen(¹O₂) in the curcumin catalyzed by copper ion was studied using 1,3-diphenylisobenzofuran(DPBF) as a selective fluorescence probe. The absorption spectrum of curcumin(CUR) binding to copper ion demonstrated the formation of copper ion-CUR complexes. This complexes were further oxidized by H₂O₂ giving rise to singlet oxygen, which was similar to Haber-Weiss reaction. That the metal ions catalyzed curcumin to produce ¹O₂ was tested. Except for Cu²⁺ and Cu⁺-CUR systems, no detectable ¹O₂ was produced in other metal ion-CUR systems. A new method was found for determining ¹O₂ in the curcumin system by catalysis of Cu²⁺. A linear relationship was obtained between ΔI_F and the concentration of ¹O₂ in the range of 1.37×10^-8—3.66×10^-7 mol/L. The detection limit was 4.12×10^-9 mol/L.

Key words: 1,3-Diphenylisobenzofuran, Curcumin, Singlet oxygen, Fluorescence quenching

CLC Number:

O657.39

TrendMD:

LÜ Qing-Luan, ZHANG Miao, YUE Ning-Ning, GONG Bin, WANG Huai-You^*. Production Mechanism Study of Singlet Oxygen in Copper Ion-Catalyzed Curcumin Using Fluorimetric Method and Its Determination in the Presence of Superoxide Anion Radical[J]. Chem. J. Chinese Universities, doi: .

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Production Mechanism Study of Singlet Oxygen in Copper Ion-Catalyzed Curcumin Using Fluorimetric Method and Its Determination in the Presence of Superoxide Anion Radical

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