Chem. J. Chinese Universities ›› 1998, Vol. 19 ›› Issue (S1): 25.
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Jieping Zhu
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Abstract: RA-VII (1) and related bicyclic hexapeptides, isolated from Rubiaceous plants, Rubia akame,showed potent antitumor activity and in fact, RA-VII is currently undergoing phase Ⅱ clinical trial in Japan. It inhibit protein synthesis through binding,to eukaryotic 80S ribosomes, resulting in inhibition of aminoacyl-tRNA binding formation and peptidyl-tRNA translocation. The complex molecular architecture and interesting biological activity made these compounds attractive synthetic targets.
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Jieping Zhu. A Total Synthesis of RA-VII[J]. Chem. J. Chinese Universities, 1998, 19(S1): 25.
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http://www.cjcu.jlu.edu.cn/EN/Y1998/V19/IS1/25