Chem. J. Chinese Universities ›› 1998, Vol. 19 ›› Issue (S1): 26.
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Kang Zhao
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Abstract: N-alkyl hydroxylamines add to conjugated alkenoates in a "concerted" fashion with high stereoselectivity and the esulting intermediates can be easily derivatized to several classes of biologically interesting molecules such as the analogs of aminosugar and nucleoside. For example, high stereoselectivity was observed in the addition of hydroxylamine derivatives to acyclic a,b-unsaturated esters. The adducts were subsequently cyclized under mild conditions to afford a single isomer of isoxazolidin-5-ones which were converted to class of isoxazoline and isoxazolidine derivatives for the studies of their antiviral activity.
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Kang Zhao. Development of Methods for Diastereo- and Enantioselective Synthesis of Hydroxyl amine Derivatives[J]. Chem. J. Chinese Universities, 1998, 19(S1): 26.
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