Total Synthesis of 2-Methyl-7-[ω-(1H-imidazol-1-yl)ethoxy]-Isoflavone Derivatives and Their Antioxidative Activity

Chem. J. Chinese Universities

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Total Synthesis of 2-Methyl-7-[ω-(1H-imidazol-1-yl)ethoxy]-Isoflavone Derivatives and Their Antioxidative Activity

CHEN Zhan-Guo^*, ZHAO Hai-Xia, WEI Jun-Fa, LIU Bo

College of Chemistry and Material Science, Shaanxi Normal University, Xi’an 710062, China

Received:2008-03-27 Revised:1900-01-01 Online:2009-01-10 Published:2009-01-10
Contact: CHEN Zhan-Guo

Abstract

Abstract: Ten kinds of imidazolyl isoflavone derivatives were synthesized from resorcinol and substituted phenylacetic acid as start materials via five-steps. The structures of the ten target compouds were confirmed via ¹H NMR, ¹³C NMR and elemental analysis. The reaction time was shortened greatly in many reaction process by a microwave-mediated method. The antioxidative activities of ten target compounds were researched. Among them the 4'-hydroxy-2-methyl-7-[3-(1-imidazolyl) propoxy] isoflavone has a strongly capacity of scavenging radical.

Key words: Isoflavone, Imidazole, Imidazolyl isoflavone derivatives, Microwave-mediated synthesis, Antioxidative activity

CLC Number:

O621.3

TrendMD:

CHEN Zhan-Guo^*, ZHAO Hai-Xia, WEI Jun-Fa, LIU Bo. Total Synthesis of 2-Methyl-7-[ω-(1H-imidazol-1-yl)ethoxy]-Isoflavone Derivatives and Their Antioxidative Activity[J]. Chem. J. Chinese Universities, doi: .

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Total Synthesis of 2-Methyl-7-[ω-(1H-imidazol-1-yl)ethoxy]-Isoflavone Derivatives and Their Antioxidative Activity

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