Chem. J. Chinese Universities ›› 2014, Vol. 35 ›› Issue (7): 1451.doi: 10.7503/cjcu20131138

• Organic Chemistry • Previous Articles     Next Articles

Synthesis and Fungicidal Activity of Novel Daphneolone Analogues

XIE Ruilong1, SONG Yue2, YANG Xinling1, WANG Meizi1, LING Yun1,*()   

  1. 1. Department of Applied Chemistry, College of Science, China Agricultural University, Beijing 100193, China
    2. College of Science, Nanjing Agricultural University, Nanjing 210095, China
  • Received:2013-11-22 Online:2014-07-10 Published:2014-03-11
  • Contact: LING Yun E-mail:lyun@cau.edu.cn
  • Supported by:
    † Supported by the National Natural Science Foundation of China(No.21272266) and the National High-tech R&D Program of China(No.2011AA10A202)

Abstract:

Taking the natural product(E)-1,5-diphenylpent-2-en-1-one(A) from Stellera chamaejasma L. as the lead compound, 15 novel daphneolone derivatives containing chromone fragments were designed and prepared base on the previous work. Their structures were confirmed by Fourier transform infrared(FTIR) spectroscopy, 1H and 13C nuclear magnetic resonance(1H NMR, 13C NMR) spectrometry and elemental analysis or high-resolution mass spectrometry(HRMS). The preliminary bioassay results indicated that some compounds showed moderate to good fungicidal activities. Some target compounds showed better activity than lead compound A at 100 mg/mL. Especially, compound 6d, with inhibition rates of 87% and 86% against Rhizoctonia solani and Botrytis cinerea respectively, exhibited comparable activity with the control difenoconazole and was valuable for further optimization.

Key words: Stellera chamaejasma L., (E)-1, 5-diphenylpent-2-en-1-one, Chromone, Fungicidal activity

CLC Number: 

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