Independent Adjustable Ion Source for Accurate Mass Determination

doi:10.3969/j.issn.0251-0790.2012.06.009

Abstract

Abstract: Ambient electrospray guns were fabricated. They worked independently and could easily be set at any ambient inlet of a mass spectrometer(MS) such as Quadrupole-Time of Flight(Q-TOF) MS. By adjusting the distance and/or angle of their nozzles to the inlet, the signal intensity was dynamically regulated without any change of sample concentration and stop of the equipment. Using two of such guns, sample and calibrants were sprayed, ionized and introduced into the mass spectrometry separately but simultaneously. The peak ratio of sample to calibriant was dynamically adjusted to about 1: 1 and high accurate molecular mass was measured, with an error of -2.7?10^-6 which was -2.9?10^-6 by common internal calibrating determination. The method has been validated by a long time(>20 months) measure of different samples(>100) from various laboratories. The overall mass errors were kept within ?5?10^-6. It can be concluded that the method is facile, flexible, time- and cost-effective, and universally applicable.

Key words: Ambient electrospray gun, Adjustable double ion source quadrupole-time of flight mass spectro-meter, Accurate mass determination

CLC Number:

O657.63

TrendMD:

MA Li-Po, WANG Guang-Hui, XIN Bin, CHEN Yi. Independent Adjustable Ion Source for Accurate Mass Determination[J]. Chem. J. Chinese Universities, 2012, 33(06): 1167.

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