Rapid Detection of Active Pharmaceutical Ingredients in Drugs by Microwave Plasma Atmospheric Pressure Desorption Ionization Mass Spectrometry

doi:10.3969/j.issn.0251-0790.2012.09.011

Abstract

Abstract:

A new ionization source, termed microwave plasma atmospheric pressure desorption ionization(MWPAPDI) source, was developed. The stable plasma was generated by microwave plasma torch working at 2450 MHz at atmospheric pressure. Ar was used as working gas. The source was successfully coupled with a Corsair API-TOF time of flight mass spectrometer, and the active pharmaceutical ingredients in drugs were rapidly characterized. The speed was allowed as fast as approximate 360 samples per hour via manual sampling. In the microwave plasma environment, the hydrogen bound moiety of the active ingredients of the drug preparations was directly removed, as a result, the quasi-molecular ions of active component compounds [M+H]⁺ became the main ions and gave simple mass spectra. Without chemical reagents, MWPAPDI has the feature for direct analysis of samples with high throughput, no pollution and in real time. Therefore, the method is believed to be a useful technique for drug discovery and chemical industry.

Key words: Microwave plasma atmospheric pressure desorption ionization(MWPAPDI), Mass spectrometry, Drug, Active pharmaceutical ingredient, Rapid analysis

CLC Number:

O657.63

TrendMD:

ZHANG Ti-Qiang, JIN Wei, ZHOU Jian-Guang, ZHANG Ying, ZHU Zhi-Qiang, ZHOU Wei, JIN Qin-Han. Rapid Detection of Active Pharmaceutical Ingredients in Drugs by Microwave Plasma Atmospheric Pressure Desorption Ionization Mass Spectrometry[J]. Chem. J. Chinese Universities, 2012, 33(09): 1938.

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