Effects of Lanthanide Ions(La3+, Gd3+, Yb3+) on Production of  Reactive  Oxygen Species in Mitochondria

Chem. J. Chinese Universities

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Effects of Lanthanide Ions(La³⁺, Gd³⁺, Yb³⁺) on Production of Reactive Oxygen Species in Mitochondria

LIU Hui-Xue, YANG Xiao-Da*, WANG Kui

Department of Chemical Biology, School of Pharmaceutical Sciences, Peking
University, Beijing 100083, China

Received:2005-10-25 Revised:1900-01-01 Online:2006-06-10 Published:2006-06-10
Contact: YANG Xiao-Da

Abstract

Abstract: The effects of lanthanides(Ln) on the production of reactive oxygen species(ROS) in isolated mitochondria were investigated by fluorescence assays upon incubation with Ln³⁺. The results show that Ln³⁺(La³⁺, Gd³⁺, Yb³⁺) could reduce the rates of overall ROS production. The results obtained from experiments on xanthine/xanthine oxidative enzyme system suggest that Ln³⁺ ions can reduce the formation of ·O^-₂, but H₂O₂ did not react with Ln³⁺. The influences of Ln³⁺ on the activities of metabolize enzymes(GSH-Px and Mn-SOD) indicate that Ln³⁺ could decrease the activity of Mn-SOD, but could not affect the activity of GSH-Px. The effects of Ln³⁺ on cellular H₂O₂ level are discussed.

Key words: Lanthanide, Mitochondria, Reactive oxygen species(ROS)

CLC Number:

O614

TrendMD:

LIU Hui-Xue, YANG Xiao-Da*, WANG Kui. Effects of Lanthanide Ions(La³⁺, Gd³⁺, Yb³⁺) on Production of Reactive Oxygen Species in Mitochondria[J]. Chem. J. Chinese Universities, doi: .

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Effects of Lanthanide Ions(La³⁺, Gd³⁺, Yb³⁺) on Production of Reactive Oxygen Species in Mitochondria

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