Chem. J. Chinese Universities ›› 1982, Vol. 3 ›› Issue (3): 345.
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Cheng Dongliang, Li Zhixiao, Guo Hongda, Zhu Ziqing(Chu Tze-Tsin)
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Abstract: L(+)-ψ-ephedrine could be isomerized to D(-)-ephedrine in glacial acetic acid. The method of isomerization was rather easy as follows:A 5% solution of L(+)-ψ-ephedrine in glacial acetic acid was refluxed for twenty hours, then acetic acid was removed immediately from the mixture under diminished pressure. The residue was hydrolyzed with 2.5 N NaOHsolution. The D(-)-ephedrine oxalate was first prepared from the product of hydrolyzation and finally converted to its hydroehloride. The yield of pure product was about 31.2% of the theoretical based on the L(+)--ephedrine.
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Cheng Dongliang, Li Zhixiao, Guo Hongda, Zhu Ziqing(Chu Tze-Tsin). A STUDY ON ISOMERIZATION OF L(+)-ψ-EPHEDRINE IN GLACIAL ACETIC ACID[J]. Chem. J. Chinese Universities, 1982, 3(3): 345.
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http://www.cjcu.jlu.edu.cn/EN/Y1982/V3/I3/345