Abstract: L(+)-ψ-ephedrine could be isomerized to D(-)-ephedrine in glacial acetic acid. The method of isomerization was rather easy as follows:A 5% solution of L(+)-ψ-ephedrine in glacial acetic acid was refluxed for twenty hours, then acetic acid was removed immediately from the mixture under diminished pressure. The residue was hydrolyzed with 2.5 N NaOHsolution. The D(-)-ephedrine oxalate was first prepared from the product of hydrolyzation and finally converted to its hydroehloride. The yield of pure product was about 31.2% of the theoretical based on the L(+)--ephedrine.