Photochemical Synthesis and Characterization of Polyethyleneimine-coated Magnetic Nanogel Used as Cancer-targeted Carrier

Chem. J. Chinese Universities

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Photochemical Synthesis and Characterization of Polyethyleneimine-coated Magnetic Nanogel Used as Cancer-targeted Carrier

LIU Hong-Ling¹*, LI Jun²

1. Department of Medicine, Dezhou University, Dezhou 253023;
2. School of Public Health, Shandong University, Jinan 250012

Received:2008-04-28 Revised:1900-01-01 Online:2008-08-10 Published:2008-08-10
Contact: LIU Hong-Ling

Abstract

Abstract: The polyethyleneimine(PEI)-coated magnetic nanogel was synthesized via photochemical polymerization under UV-light irradiation. Modified with folic acid, which was expected to be able to identify tumor surface receptors and to have a high binding force with cancer cells, the FA-PEI-Fe₃O₄ nanogel was prepared. The FA-PEI-Fe₃O₄ nanogel was characterized by Fourier transform infrared spectroscopy, thermogravimetric analysis, scan electron microscope and vibrating sample magnetometer, respectively. The results showed that the magnetic nanogel was regular shape with a mean diameter of 140 nm. With high saturation magnetization and folate modification, the FA-PEI-Fe₃O₄ nanogel suggests promising potential application in cancer-targeted drug delivery.

Key words: Magnetic nanogels, Photochemical preparation, PEI, Folate, Cancer-targeted carrier

CLC Number:

O635
O644.1

TrendMD:

LIU Hong-Ling¹*, LI Jun². Photochemical Synthesis and Characterization of Polyethyleneimine-coated Magnetic Nanogel Used as Cancer-targeted Carrier[J]. Chem. J. Chinese Universities, doi: .

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Photochemical Synthesis and Characterization of Polyethyleneimine-coated Magnetic Nanogel Used as Cancer-targeted Carrier

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