Effect of Layer-by-layer Films of Natural Polymers on Drug Release of Magnetic Poly(lactic acid) Microspheres

doi:10.7503/cjcu20120534

Chem. J. Chinese Universities ›› 2012, Vol. 33 ›› Issue (12): 2779.doi: 10.7503/cjcu20120534

• Polymer Chemistry • Previous Articles Next Articles

Effect of Layer-by-layer Films of Natural Polymers on Drug Release of Magnetic Poly(lactic acid) Microspheres

FU Yu², YANG Min³, LI Yan², ZHONG Chong-Bin², JIAO Yong-Hua², LIN Ao-Lei¹

1. State Key Laboratory of Superhard Materials, Jilin University, Changchun 130012, China;
2. College of Sciences, Northeastern University, Shenyang 110004, China;
3. Beijing Health School, Beijing 100053, China

Received:2012-06-04 Online:2012-12-10 Published:2012-11-20
Contact: LIN AoLei E-mail:linal@jlu.edu.cn

Abstract

Abstract:

Polylactic acid(PLA) microsphere is an ideal drug carrier with high tolerance to the human body and the capability of carrying a wide range of drugs. However, the burst release of drug from the drug-loaded microspheres limit its effective application. Constructing a barrier layer at the surface of microspheres is an effective way to control the burst release of drug. A barrier layer consisting of natural polymer chitosan and sodium alginate was constructed by employing the layer-by-layer assembly technology. Furthermore, the effect of the layer on the drug release from magnetic PLA microsphere was investigated. The experimental results demonstrated that the barrier layer could effectively restrain the burst release of model drug, thus delaying the drug release. The magnetic drug delivery system constructed in this study is a promising magnetic targeted drug delivery system which allows the sustained release of drug and has high biocompatibility.

Key words: Poly(lactic acid) microsphere, Magnetic nanoparticles, Layer-by-layer self-assembly, Sustained-release of drug

CLC Number:

O631

TrendMD:

FU Yu, YANG Min, LI Yan, ZHONG Chong-Bin, JIAO Yong-Hua, LIN Ao-Lei. Effect of Layer-by-layer Films of Natural Polymers on Drug Release of Magnetic Poly(lactic acid) Microspheres[J]. Chem. J. Chinese Universities, 2012, 33(12): 2779.

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Effect of Layer-by-layer Films of Natural Polymers on Drug Release of Magnetic Poly(lactic acid) Microspheres

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